Browsing by Author "Sneha, P"
Now showing items 1-6 of 6
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Computational approach to unravel the impact of missense mutations of proteins (D2HGDH and IDH2) causing D-2-hydroxyglutaric aciduria 2.
Thirumal Kumar, D; Jerushah Emerald, L; George Priya Doss, C; Sneha, P; Siva, R; Charles Emmanuel Jebaraj, W; Zayed, Hatem... more authors ... less authors ( Springer US , 2018 , Article)The 2-hydroxyglutaric aciduria (2-HGA) is a rare neurometabolic disorder that leads to the development of brain damage. It is classified into three categories: D-2-HGA, L-2-HGA, and combined D,L-2-HGA. The D-2-HGA includes ... -
Genetic Epidemiology of Glucose-6-Dehydrogenase Deficiency in the Arab World
Doss, C. George Priya; Alasmar, Dima R.; Bux, Reem I.; Sneha, P.; Bakhsh, Fadheela Dad; Al-Azwani, Iman; El Bekay, Rajaa; Zayed, Hatem... more authors ... less authors ( Nature Publishing Group , 2016 , Article)A systematic search was implemented using four literature databases (PubMed, Embase, Science Direct and Web of Science) to capture all the causative mutations of Glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDD) ... -
Impact of missense mutations in survival motor neuron protein (SMN1) leading to Spinal Muscular Atrophy (SMA): A computational approach.
Sneha, P; Zenith, Tanzila U; Abu Habib, Ummay Salma; Evangeline, Judith; Thirumal Kumar, D; George Priya Doss, C; Siva, R; Zayed, Hatem... more authors ... less authors ( Springer US , 2018 , Article)Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by the mutations in survival motor neuron 1 gene (SMN1). The molecular pathology of missense mutations in SMN1 is not thoroughly investigated so far. Therefore, ... -
Implication of salt stress induces changes in pigment production, antioxidant enzyme activity, and qRT-PCR expression of genes involved in the biosynthetic pathway of Bixa orellana L.
Sankari, M; Hridya, H; Sneha, P; Doss, C George Priya; Christopher, J Godwin; Mathew, Jill; Zayed, Hatem; Ramamoorthy, Siva... more authors ... less authors ( Springer Verlag , 2019 , Article)The effect of salt stress on pigment synthesis and antioxidant enzyme activity as well as in the genes involved in the biosynthetic pathway of bixin was studied. The 14-day germinated seedlings of Bixa orellana were induced ... -
Molecular dynamics-based analyses of the structural instability and secondary structure of the fibrinogen gamma chain protein with the D356V mutation.
Ali, Shabana Kouser; Sneha, P; Priyadharshini Christy, J; Zayed, Hatem; George Priya Doss, C ( Taylor & Francis , 2016 , Article)Mutations in the fibrinogen gamma chain (FGG) gene have been associated with various disorders, such as dysfibrinogenemia, thrombophilia, and hypofibrinogenemia. A literature survey showed that a residue exchange in ... -
A profound computational study to prioritize the disease-causing mutations in PRPS1 gene.
Agrahari, Ashish Kumar; Sneha, P; George Priya Doss, C; Siva, R; Zayed, Hatem ( Springer Verlag , 2017 , Article)Charcot-Marie-Tooth disease (CMT) is one of the most commonly inherited congenital neurological disorders, affecting approximately 1 in 2500 in the US. About 80 genes were found to be in association with CMT. The phosphoribosyl ...