Browsing by Author "Iskandarani A."
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Greensporone A, a fungal secondary metabolite suppressed constitutively activated AKT via ROS generation and induced apoptosis in leukemic cell lines
Prabhu K.S.; Siveen K.S.; Kuttikrishnan S.; Jochebeth A.; Ali T.A.; Elareer N.R.; Iskandarani A.; Khan A.Q.; Merhi M.; Dermime S.; El-Elimat T.; Oberlies N.H.; Alali F.Q.; Steinhoff M.; Uddin S.... more authors ... less authors ( MDPI AG , 2019 , Article)Greensporone A is a fungal secondary metabolite that has exhibited potential in vitro for anti-proliferative activity in vitro. We studied the anticancer activity of greensporone A in a panel of leukemic cell lines. ... -
The replacement of five consecutive amino acids in the cyt1a protein of bacillus thuringiensis enhances its cytotoxic activity against lung epithelial cancer cells
Nair K.; Iskandarani A.; Al-Thani R.; Mohammad R.; Jaoua S. ( MDPI AG , 2018 , Article)Cyt1A protein is a cytolytic protein encoded by the cyt gene of Bacillus thuringiensis subsp. israelensis (Bti) as part of the parasporal crystal proteins produced during the sporulation. Cyt1A protein is unique compared ...