تصفح حسب المؤلف "Majbour, Nour K."
-
Cerebrospinal fluid α-synuclein species in cognitive and movements disorders
Constantinides, Vasilios C.; Majbour, Nour K.; Paraskevas, George P.; Abdi, Ilham; Safieh-Garabedian, Bared; Stefanis, Leonidas; El-Agnaf, Omar M.; Kapaki, Elisabeth... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Total CSF α-synuclein (t-α-syn), phosphorylated α-syn (pS129-α-syn) and α-syn oligomers (o-α-syn) have been studied as candidate biomarkers for synucleinopathies, with suboptimal specificity and sensitivity in the ... -
Cerebrospinal α-Synuclein Oligomers Reflect Disease Motor Severity in DeNoPa Longitudinal Cohort
Majbour, Nour K.; Abdi, Ilham Y.; Dakna, Mohammed; Wicke, Tamara; Lang, Elisabeth; Ali Moussa, Houda Y.; Thomas, Mercy A.; Trenkwalder, Claudia; Safieh-Garabedian, Bared; Tokuda, Takahiko; Mollenhauer, Brit; El-Agnaf, Omar... more authors ... less authors ( Wiley , 2021 , Article)Background: Tangible efforts have been made to identify biomarkers for Parkinson's disease (PD) diagnosis and progression, with α-synuclein (α-syn) related biomarkers being at the forefront. Objectives: The objectives of ... -
Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity
Gupta, Vijay; Salim, Safa; Hmila, Issam; Vaikath, Nishant N.; Sudhakaran, Indulekha P.; Ghanem, Simona S.; Majbour, Nour K.; Abdulla, Sara A.; Emara, Mohamed M.; Abdesselem, Houari B.; Lukacsovich, Tamas; Erskine, Daniel; El-Agnaf, Omar M.A.... more authors ... less authors ( Springer Nature , 2020 , Article)Synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) are characterized by pathological accumulation of α-synuclein (α-syn). Amongst the various approaches ... -
Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity.
Hmila, Issam; Vaikath, Nishant N; Majbour, Nour K; Erskine, Daniel; Sudhakaran, Indulekha P; Gupta, Vijay; Ghanem, Simona S; Islam, Zeyaul; Emara, Mohamed M; Abdesselem, Houari B; Kolatkar, Prasanna R; Achappa, Devaya K; Vinardell, Tatiana; El-Agnaf, Omar M A... more authors ... less authors ( FEBS PRESS , 2022 , Article)Nanobodies (Nbs), the single-domain antigen-binding fragments of dromedary heavy-chain antibodies (HCAb), are excellent candidates as therapeutic and diagnostic tools in synucleinopathies because of their small size, ... -
Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
Majbour, Nour K.; Vaikath, Nishant N.; van Dijk, Karin D.; Ardah, Mustafa T.; Varghese, Shiji; Vesterager, Louise B.; Montezinho, Liliana P.; Poole, Stephen; Safieh-Garabedian, Bared; Tokuda, Takahiko; Teunissen, Charlotte E.; Berendse, Henk W.; van de Berg, Wilma D. J.; El-Agnaf, Omar M. A.... more authors ... less authors ( BioMed Central , 2016 , Article)Background Despite decades of intensive research, to date, there is no accepted diagnosis for Parkinson’s disease (PD) based on biochemical analysis of blood or CSF. However, neurodegeneration in the brains of PD patients ...