تصفح حسب المؤلف "Zonfrillo, Manuela"
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Aspirin inhibits cancer stem cells properties and growth of glioblastoma multiforme through Rb1 pathway modulation.
Pozzoli, Giacomo; Marei, Hany E; Althani, Asma; Boninsegna, Alma; Casalbore, Patrizia; Marlier, Lionel N J L; Lanzilli, Giulia; Zonfrillo, Manuela; Petrucci, Giovanna; Rocca, Bianca; Navarra, Pierluigi; Sgambato, Alessandro; Cenciarelli, Carlo... more authors ... less authors ( Wiley , 2019 , Article)Several clinical studies indicated that the daily use of aspirin or acetylsalicylic acid reduces the cancer risk via cyclooxygenases (Cox-1 and Cox-2) inhibition. In addition, aspirin-induced Cox-dependent and -independent ... -
The Interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets
Cenciarelli, Carlo; E. Marei, Hany; Zonfrillo, Manuela; Casalbore, Patrizia; Felsani, Armando; Trevisi, Gianluca; Althani, Asma; Mangiola, Annunziato... more authors ... less authors ( Impact Journals , 2017 , Article)The invasive and lethal nature of Glioblastoma multiforme (GBM) necessitates the continuous identification of molecular targets and search of efficacious therapies to inhibit GBM growth. The GBM resistance to chemotherapy ...