Browsing by Author "Sampath, Chethan"
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Bioactive Components from Ginger, Tea and Apple Prevent Protein Glycation by Trapping Methylglyoxal with Potential in Alleviation of Diabetic Complications
Sang, Shengmin; Zhu, Yingdong; Wang, Pei; Zhao, Yantao; Sampath, Chethan; Ahmedna, Mohamed... more authors ... less authors ( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)Diabetes is the fifth-deadliest disease in the United States. Most diabetes patients die from diabetic complications, such as renal failure, heart attack or stroke. However, diabetic complications are still neither preventable ... -
Bioactive compounds isolated from apple, tea, and ginger protect against dicarbonyl induced stress in cultured human retinal epithelial cells
Sampath, Chethan; Zhu, Yingdong; Sang, Shengmin; Ahmedna, Mohamed ( Elsevier , 2016 , Article)Abstract BackgroundMethylglyoxal (MGO) is known to be a major precursor of advanced glycation end products (AGEs) which are linked to diabetes and its related complications. Naturally occurring bioactive compounds could ... -
Green tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity
Sampath, Chethan; Rashid, Muhammed Raihan; Sang, Shengmin; Ahmedna, Mohamed ( Elsevier , 2017 , Article)Abstract Epigallocatechin 3-gallate (EGCG) from green tea may reduce plasma glucose and alleviate complications of diabetes by attenuating advanced glycation end products (AGEs) formation. We hypothesized that EGCG would ... -
In vitro and in vivo inhibition of aldose reductase and advanced glycation end products by phloretin, epigallocatechin 3-gallate and [6]-gingerol
Sampath, Chethan; Sang, Shengmin; Ahmedna, Mohamed ( Elsevier , 2016 , Article)Abstract Hyperglycemic stress activates polyol pathway and aldose reductase (AR) key enzyme responsible for generating secondary complications during diabetes. In this study the therapeutic potential of phloretin, ... -
Specific Bioactive Compounds from Ginger, Tea, and Apple Prevent Diabetes-Related Cataract Via Inhibition of Aldose Reducatse
Ahmedna, Mohamed; Sampath, Chethan; Sang, Shengmin ( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, United States Abstract Chronic hyperglycemia is an important risk factor involved in the onset and progression of secondary complications of diabetes. ... -
Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway
Sampath, Chethan; Rashid, Muhammed; Sang, Shengmin; Ahmedna, Mohamed ( Elsevier , 2017 , Article)Prolonged hyperglycemia activates the formation of advanced glycation end-products (AGEs). Major dicarbonyl compounds such as methylglyoxal or glyoxal are found to be the main precursors of AGEs and N(e)-(carboxymethyl)lysine ...