Browsing by Author "Korashy, Hesham M."
Now showing items 21-33 of 33
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MOLECULAR FEATURES OF TRIPLE NEGATIVE BREAST CANCER STEM CELLS: A GENE EXPRESSION PROFILING ANALYSIS OF MDA-MB-231 CELLS
Hourani, Shireen Bayan (2021 , Master Thesis)Triple negative breast cancer (TNBC) is a chemoresistant subtype of female breast tumors. Chemoresistance is attributed to the presence of long-lived cancer stem cells (CSCs) responsible for therapy failure. This study ... -
Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling
Ghantous, Crystal M.; Farhat, Rima; Djouhri, Laiche; Alashmar, Sarah; Anlar, Gulsen; Korashy, Hesham M.; Agouni, Abdelali; Zeidan, Asad... more authors ... less authors ( hindawi , 2020 , Article)Hypertension induces vascular hypertrophy, which changes blood vessels structurally and functionally, leading to reduced tissue perfusion and further hypertension. It is also associated with dysregulated levels of the ... -
A novel approach of encapsulating curcumin and succinylated derivative in mannosylated-chitosan nanoparticles
Idoudi, Sourour; Hijji, Yousef; Bedhiafi, Takwa; Korashy, Hesham M.; Uddin, Shahab; Merhi, Maysaloun; Dermime, Said; Billa, Nashiru... more authors ... less authors ( Elsevier , 2022 , Article)Curcumin (CUR) manifests anti-colon cancer activity but suffers from low solubility, bioavailability, and instability, rendering it not as effective as its chemotherapeutic cousins. Here, we conjugate CUR to succinic ... -
Protein tyrosine phosphatase 1B inhibition improves endoplasmic reticulum stress-impaired endothelial cell angiogenic response: A critical role for cell survival
ABDELSALAM, SHAHENDA S.; PASHA, MAZHAR; EL-GAMAL, HEBA; HASAN, MARAM; ELRAYESS, MOHAMED A.; ZEIDAN, ASAD; KORASHY, HESHAM M.; AGOUNI, ABDELALI... more authors ... less authors ( Spandidos publications , 2021 , Article)Endoplasmic reticulum (ER) stress contributes to endothelial dysfunction, which is the initial step in atherogenesis. Blockade of protein tyrosine phosphatase (PTP)1B, a negative regulator of insulin receptors that is ... -
Reduced Cardiotoxicity of Ponatinib-Loaded PLGA-PEG-PLGA Nanoparticles in Zebrafish Xenograft Model.
Al-Thani, Hissa F; Shurbaji, Samar; Zakaria, Zain Zaki; Hasan, Maram H; Goracinova, Katerina; Korashy, Hesham M; Yalcin, Huseyin C... more authors ... less authors ( MDPI , 2022 , Article)Tyrosine kinase inhibitors (TKIs) are the new generation of anti-cancer drugs with high potential against cancer cells' proliferation and growth. However, TKIs are associated with severe cardiotoxicity, limiting their ... -
Regulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways
Lubna, Therachiyil; Hussein, Ola J.; Uddin, Shahab; Korashy, Hesham M. ( Elsevier , 2022 , Article Review)Gynecological malignancies are a female type of cancers that affects the reproductive system. Cancer metastasis or recurrence mediated by cellular invasiveness occurs at advanced stages of cancer progression. Cancer Stem ... -
The role of NF-κB and AhR transcription factors in lead-induced lung toxicity in human lung cancer A549 cells.
Attafi, Ibraheem M; Bakheet, Saleh A; Korashy, Hesham M ( Taylor & Francis , 2019 , Article)Lead (Pb) is recognized as the first heavy metal of the top six toxic air pollutants threatening human health and the second hazardous substance. Pb exposure is associated with lung impairment and high incidences of lung ... -
The Role of p90 Ribosomal S6 Kinase (RSK) in Tyrosine Kinase Inhibitor (TKI)-Induced Cardiotoxicity
Suleiman, Muna; Al Najjar, Afnan; Zakaria, Zain Z.; Ahmed, Rashid; Yalcin, Huseyin C.; Korashy, Hesham M.; Uddin, Shahab; Riaz, Sadaf; Abdulrahman, Nabeel; Mraiche, Fatima... more authors ... less authors ( Springer , 2023 , Article Review)Targeted therapy, such as tyrosine kinase inhibitors (TKIs), has been approved to manage various cancer types. However, TKI-induced cardiotoxicity is a limiting factor for their use. This issue has raised the need for ... -
The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin Resistance.
Abdelsalam, Shahenda S; Korashy, Hesham M; Zeidan, Asad; Agouni, Abdelali ( MDPI , 2019 , Article Review)Endothelial dysfunction is a key feature of cardiovascular disorders associated with obesity and diabetes. Several studies identified protein tyrosine phosphatase (PTP)-1B, a member of the PTP superfamily, as a major ... -
Role of RAS signaling in ovarian cancer
Uddin, Shahab; Therachiyil, Lubna; Anand, Anjana; Azmi, Abdullah; Bhat, Ajaz; Korashy, Hesham M.... more authors ... less authors ( Taylor & Francis , 2022 , Article)The RAS family of proteins is among the most frequently mutated genes in human malignancies. In ovarian cancer (OC), the most lethal gynecological malignancy, RAS, especially KRAS mutational status at codons 12, 13, and ... -
Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress
Fatima, Munazza T; Hasan, Maram; Abdelsalam, Shahenda S; Sivaraman, Siveen K; El-Gamal, Heba; Zahid, Muhammad A; Elrayess, Mohamed A; Korashy, Hesham M; Zeidan, Asad; Parray, Aijaz S; Agouni, Abdelali... more authors ... less authors ( Elsevier , 2021 , Article)Endoplasmic reticulum (ER) stress is an inflammatory response that contributes to endothelial dysfunction, a hallmark of cardiovascular diseases, in close interplay with oxidative stress. Recently, Sestrin2 (SESN2) emerged ... -
The role of protein tyrosine phosphatase (PTP)-1B in cardiovascular disease and its interplay with insulin resistance
Abdelsalam, Shahenda S.; Korashy, Hesham M.; Zeidan, Asad; Agouni, Abdelali ( MDPI AG , 2019 , Article Review)Endothelial dysfunction is a key feature of cardiovascular disorders associated with obesity and diabetes. Several studies identified protein tyrosine phosphatase (PTP)-1B, a member of the PTP superfamily, as a major ... -
Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development.
Rayan, Menatallah; Sayed, Tahseen S; Hussein, Ola J; Therachiyil, Lubna; Maayah, Zaid H; Maccalli, Cristina; Uddin, Shahab; Prehn, Jochen H M; Korashy, Hesham M... more authors ... less authors ( Springer Nature , 2024 , Article)Gut microbiota regulates various aspects of human physiology by producing metabolites, metabolizing enzymes, and toxins. Many studies have linked microbiota with human health and altered microbiome configurations with the ...