Browsing by Author "Abdulrahman N."
Now showing items 1-3 of 3
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Cisplatin based therapy: The role of the mitogen activated protein kinase signaling pathway
Achkar I.W.; Abdulrahman N.; Al-Sulaiti H.; Joseph J.M.; Uddin S.; Mraiche F.... more authors ... less authors ( BioMed Central Ltd. , 2018 , Article Review)Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance and several adverse side effects such as nephrotoxicity, reduced ... -
Na + /H + exchanger isoform 1-induced osteopontin expression facilitates cardiac hypertrophy through p90 ribosomal S6 kinase
Abdulrahman N.; Jaspard-Vinassa B.; Fliegel L.; Jabeen A.; Riaz S.; Gadeau A.-P.; Mraiche F.... more authors ... less authors ( NLM (Medline) , 2018 , Article)Cardiovascular diseases are the leading cause of death worldwide. One in three cases of heart failure is due to dilated cardiomyopathy. The Na+/H+ exchanger isoform 1 (NHE1), a multifunctional protein and the key pH regulator ... -
Osteopontin: A Promising Therapeutic Target in Cardiac Fibrosis
Abdelaziz Mohamed I.; Gadeau A.-P.; Hasan, Anwarul; Abdulrahman N.; Mraiche F. ( NLM (Medline) , 2019 , Article)Osteopontin (OPN) is recognized for its significant roles in both physiological and pathological processes. Initially, OPN was recognized as a cytokine with pro-inflammatory actions. More recently, OPN has emerged as a ...