Browsing by Author "Rachid, Ousama"
Now showing items 1-20 of 25
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A protocol to investigate the stability of 0.9% sodium chloride IV fluid bags in the prehospital setting of Qatar
Makhlouf, Ahmed; Alinier, Guillaume; Kerkeni, Habib; Al Shaikh, Loua; Rachid, Ousama ( Hamad bin Khalifa University Press (HBKU Press) , 2022 , Article)Background: 0.9% sodium chloride (NaCl) fluid bags are commonly stored in ambulances. Despite that the ambulances normally use air-conditioning during operational shifts, NaCl bags are exposed to deviations from the ... -
A systematic review of stability of medicines used in emergency medical service settings
Rachid, Ousama; Obasi, Joy; Mohamed Ibrahim, MohamedIzham; Diab, Mohammad; Al-Moslih, Ayad; Makhlouf, Ahmed; Alinier, Guillaume... more authors ... less authors ( Hamad bin Khalifa University Press (HBKU Press) , 2020 , Article)Background: Temperature, among several environment conditions like humidity, is known to impact medicine stability 1,2 . In emergency medical service (EMS) settings, it is often challenging to control these conditions. In ... -
Can we use normal saline stored under stress conditions? A simulated prehospital emergency medical setting
Rachid, Ousama; Akkbik, Mohammed; Alkilany, Alaaldin M.; Makhlouf, Ahmed; Al Shaikh, Loua; Alinier, Guillaume... more authors ... less authors ( Elsevier Ltd , 2023 , Article)Background: Data on stability and suitability to use normal saline stored under stress conditions in ambulances is lacking. Objective: We aimed to study the impact of exposure to extreme temperature variations on normal ... -
Comprehensive evaluation of the pharmacological and toxicological effects of γ-valerolactone as compared to γ-hydroxybutyric acid: Insights from in vivo and in silico models
Arfè, Raffaella; Bilel, Sabrine; Tirri, Micaela; Corli, Giorgia; Bergamin, Eva; Serpelloni, Giovanni; Bassi, Marta; Borsari, Martina; Boccuto, Federica; Bernardi, Tatiana; Caruso, Lorenzo; Alkilany, Alaaldin M.; Rachid, Ousama; Botrè, Francesco; De-Giorgio, Fabio; Marti, Matteo... more authors ... less authors ( Elsevier , 2023 , Article)Γ-valerolactone (GVL), marketed online as “Tranquilli-G” and “excellent Valium”, is used as a legal substitute for γ-hydroxybutyric acid (GHB); however, until now, GVL has only been connected to one Drug-Facilitated Sexual ... -
Creation of an inventory of quality markers used to evaluate pharmacokinetic literature: A systematic review
Soliman, Alaa Bahaa Eldeen; Pawluk, Shane Ashley; Wilby, Kyle John; Rachid, Ousama ( Wiley , 2021 , Article Review)What is known and objective: Robust critical appraisal tools for clinical pharmacokinetic studies are limited. Before development of such a tool is possible, quality markers (items deemed important for credibility of study ... -
CTLA4-Ig (abatacept): a promising investigational drug for use in type 1 diabetes.
Rachid, Ousama; Osman, Aisha; Abdi, Reza; Haik, Yousef ( Taylor & Francis , 2020 , Article Review)Type 1 diabetes (T1D) is an autoimmune disease that results from the destruction of insulin-producing beta cells in the pancreas; it leads to the under or nonproduction of insulin. T1D is associated with numerous ... -
Development of a college-level assessment framework in line with international accreditation standards: A Middle Eastern perspective.
Wilby, Kyle John; Zolezzi, Monica; Rachid, Ousama; El-Kadi, Ayman ( Elsevier , 2017 , Article)Accreditation of international pharmacy programs by North American and European accrediting bodies is becoming increasingly popular. Practices regarding assessment and evaluation are especially highlighted in accreditation ... -
Development of a protocol to investigate the stability of drugs used by Qatar's National Ambulance Service in rapid response vehicles
Rachid, Ousama; Makhlouf, Ahmed; Abdulselam, Meral; Benammar, Sarra; Omer, Elaf; AlDakhakhny, Salma; Abolward, Alzahraa; Kerkeni, Habib; Al Shaikh, Loua; Alinier, Guillaume... more authors ... less authors ( Hamad bin Khalifa University Press (HBKU Press) , 2022 , Article)Background: Paramedics need a range of medications that are stored in bags for easy transportation to the patient's side and are exposed to temperature variations, especially in a hot country like Qatar 1 . The thermal ... -
Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential
Kheraldine, Hadeel; Rachid, Ousama; M Habib, Abdella; Al Moustafa, Ala-Eddin; F. Benter, Ibrahim ( Elsevier , 2021 , Article)Drug delivery systems or vectors are usually needed to improve the bioavailability and effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an organ, tissue or cellular level. However, emerging ... -
Epinephrine in anaphylaxis: Preclinical study of pharmacokinetics after sublingual administration of taste-masked tablets for potential pediatric use
Rachid, Ousama; Rawas-Qalaji, Mutasem; Simons, Keith J. ( MDPI AG , 2018 , Article)Epinephrine is a life-saving treatment in anaphylaxis. In community settings, a first-aid dose of epinephrine is injected from an auto-injector (EAI). Needle phobia highly contributes to EAI underuse, leading to ... -
The Impact of Pamam Dendrimers on Her2-Positive Breast Cancer and the Early Stages of Embryogenesis
Kheraldine, Hadeel (2020 , Master Thesis)Poly (amidoamine) (PAMAM) dendrimers are widely used in drug delivery systems and gene transfection as drug carriers. They also exert several biological effects including modulating gene expression and interfering with ... -
In Vivo Evaluation of Taste-Masked Fast-Disintegrating Sublingual Tablets of Epinephrine Microcrystals
Rachid, Ousama; Simons, Keith J.; Rawas-Qalaji, Mutasem ( Springer New York LLC , 2018 , Article)n community settings, IM injection of 0.3 mg epinephrine (Epi) using an auto-injector is the drug of choice for treatment of anaphylaxis. Previously, a taste-masking (TM) formulation of fast-disintegrating sublingual tablets ... -
Intravenous fluids in hot pre-hospital environments: Thermal and physical stability of normal saline after exposure to simulated stress conditions
Rachid, Ousama; Akkbik, Mohammed; Makhlouf, Ahmed; Moslih, Ayad; Al Shaikh, Loua; Alinier, Guillaume... more authors ... less authors ( Hamad bin Khalifa University Press (HBKU Press) , 2022 , Article)Background: Normal saline 0.9 % (NS) is the most widespread crystalloid used as a life-saving intravenous (IV) fluid. 1 NS contains sodium and chloride in equal concentrations and is subject to thermal stress conditions ... -
Monitoring temperature and humidity in ambulance service rapid-response vehicles and paramedics medication bags: A pilot study
Rachid, Ousama; Makhlouf, Ahmed; Kerkeni, Habib; Alinier, Guillaume ( Hamad bin Khalifa University Press (HBKU Press) , 2022 , Article)Background: In the pre-hospital context, paramedics carry medications in multi-compartment medication bags. However, these medications are occasionally subjected to temperature and humidity variations as they are being ... -
Naked Poly(amidoamine) Dendrimer Nanoparticles Exhibit Intrinsic Embryotoxicity During the Early Stages of Normal Development.
Kheraldine, Hadeel; Gupta, Ishita; Alhussain, Hashim; Jabeen, Ayesha; Akhtar, Saghir; Al Moustafa, Ala-Eddin; Rachid, Ousama... more authors ... less authors ( American Science Publishers ASP , 2020 , Article)To investigate the impact of poly(amidoamine) dendrimers (PAMAMs) in the embryo, we explored the outcome of different generations (G₄ and G) on the early stages of embryogenesis using the chicken embryo as a model. We also ... -
PAMAM Dendrimers as Anti-HER2 Positive Breast Cancer Treatment
Kheraldine, Hadeel; Akhtar, Saghir; Al Moustafa, Ala-Eddin; Rachid, Ousama ( Qatar University Press , 2020 , Poster)Background: Poly (amidoamine) dendrimers (PAMAMs) are widely used in drug delivery systems and gene transfection as drug carriers. They also exert several biological effects like modulating gene expression, particularly ... -
Pharmaceutical Characterization of MyoNovin, a Novel Skeletal Muscle Regenerator: in silico, in vitro and in vivo Studies.
Alrushaid, Samaa; Davies, Neal M; Anderson, Judy E; Le, Tyson; Yáñez, Jaime A; Maayah, Zaid H; El-Kadi, Ayman O S; Rachid, Ousama; Sayre, Casey L; Löbenberg, Raimar; Burczynski, Frank J... more authors ... less authors ( Canadian Society for Pharmaceutical Sciences , 2018 , Article)MyoNovin is a novel skeletal muscle-regenerating compound developed through synthesis of two nitro groups onto a guaifenesin backbone to deliver nitric oxide to skeletal muscle with a potential to treat muscle atrophy. The ... -
Pharmaco-toxicological effects of the novel tryptamine hallucinogen 5-MeO-MiPT on motor, sensorimotor, physiological, and cardiorespiratory parameters in mice—from a human poisoning case to the preclinical evidence
Bassi, Marta; Bilel, Sabrine; Tirri, Micaela; Corli, Giorgia; Di Rosa, Fabiana; Gregori, Adolfo; Alkilany, Alaaldin M.; Rachid, Ousama; Roda, Elisa; Zauli, Giorgio; Locatelli, Carlo Alessandro; Marti, Matteo... more authors ... less authors ( Springer Nature , 2024 , Article)Rationale: The 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT, known online as “Moxy”) is a new psychedelic tryptamine first identified on Italian national territory in 2014. Its hallucinogen effects are broadly ... -
PLGA-Gold Nanocomposite: Preparation and Biomedical Applications
Alkilany, Alaaldin M.; Rachid, Ousama; Alkawareek, Mahmoud Y.; Billa, Nashiru; Daou, Anis; Murphy, Catherine J.... more authors ... less authors ( MDPI , 2022 , Article)A composite system consisting of both organic and inorganic nanoparticles is an approach to prepare a new material exhibiting “the best of both worlds”. In this review, we highlight the recent advances in the preparation ... -
Rivaroxaban Pharmacokinetics in Obese Subjects: A Systematic Review
Alalawneh, Majdoleen; Awaisu, Ahmed; Rachid, Ousama ( Springer Nature , 2022 , Article)Venous thromboembolism (VTE) is a leading cause of morbidity and mortality globally. The direct oral anticoagulants, including rivaroxaban, are relatively novel therapeutic options in the treatment and prevention of VTE. ...