Browsing by Author "Mangiola, Annunziato"
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The Interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets
Cenciarelli, Carlo; E. Marei, Hany; Zonfrillo, Manuela; Casalbore, Patrizia; Felsani, Armando; Trevisi, Gianluca; Althani, Asma; Mangiola, Annunziato... more authors ... less authors ( Impact Journals , 2017 , Article)The invasive and lethal nature of Glioblastoma multiforme (GBM) necessitates the continuous identification of molecular targets and search of efficacious therapies to inhibit GBM growth. The GBM resistance to chemotherapy ... -
PDGFRα depletion attenuates glioblastoma stem cells features by modulation of STAT3, RB1 and multiple oncogenic signals.
Cenciarelli, Carlo; Marei, Hany E.; Felsani, Armando; Casalbore, Patrizia; Sica, Gigliola; Puglisi, Maria Ausiliatrice; Cameron, Angus J.M.; Olivi, Alessandro; Mangiola, Annunziato... more authors ... less authors ( Impact Journals , 2016 , Article)Platelet derived growth factor receptors (PDGFRs) play an important role in tumor pathogenesis, and they are frequently overexpressed in glioblastoma (GBM). Earlier we have shown a higher protein expression of PDGFR isoforms ...