Browsing by Author "de la Fuente, Alberto"
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Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome
Alhujaily, Muhanad; Abbas, Hafsa; Xue, Mingzhan; de la Fuente, Alberto; Rabbani, Naila; Thornalley, Paul J.... more authors ... less authors ( Frontiers Media S.A. , 2021 , Article)Background: Tumor glycolysis is a target for cancer chemotherapy. Methylglyoxal (MG) is a reactive metabolite formed mainly as a by-product in anaerobic glycolysis, metabolized by glyoxalase 1 (Glo1) of the glyoxalase ... -
Vulnerabilities of the SARS-CoV-2 Virus to Proteotoxicity—Opportunity for Repurposed Chemotherapy of COVID-19 Infection
Al-Motawa, Maryam S.; Abbas, Hafsa; Wijten, Patrick; de la Fuente, Alberto; Xue, Mingzhan; Rabbani, Naila; Thornalley, Paul J.... more authors ... less authors ( Frontiers Media , 2020 , Article)The global pandemic of COVID-19 disease caused by infection with the SARS-CoV-2 coronavirus, has produced an urgent requirement and search for improved treatments while effective vaccines are developed. A strategy for ...