Browsing by Author "Sahebkar, Amirhossein"

Now showing items 21-32 of 32

    • Global Burden of Cardiovascular Diseases and Risks, 1990-2022 

      George A., Mensah; Fuster, Valentin; Murray, Christopher J.L.; Roth, Gregory A.; Mensah, George A.; ... more authors ( Elsevier , 2023 , Other)
      The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) is a multinational collaborative research study with >10,000 collaborators around the world. GBD generates a time series of summary measures of health, ...

    • Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021 

      Natalia V, Bhattacharjee; Schumacher, Austin E; Aali, Amirali; Abate, Yohannes Habtegiorgis; Abbasgholizadeh, Rouzbeh; ... more authors ( Elsevier , 2024 , Article)
      BackgroundAccurate assessments of current and future fertility—including overall trends and changing population age structures across countries and regions—are essential to help plan for the profound social, economic, ...

    • Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 

      Jaimie D, Steinmetz; Seeher, Katrin Maria; Schiess, Nicoline; Nichols, Emma; Cao, Bochen; ... more authors ( Elsevier , 2024 , Article)
      BackgroundDisorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous ...

    • Inflammation and hypertension: Underlying mechanisms and emerging understandings 

      Aboukhater, Diana; Morad, Bassel; Nasrallah, Nadim; Nasser, Suzanne A.; Sahebkar, Amirhossein; ... more authors ( wiley online library , 2023 , Article Review)
      Hypertension remains a major contributor to cardiovascular disease (CVD), a leading cause of global death. One of the major insults that drive increased blood pressure is inflammation. While it is the body's defensive ...

    • Intermittent fasting favorably modulates adipokines and potentially attenuates atherosclerosis 

      Al Zein, Mohammad; Zein, Omar; Diab, Rawan; Dimachkie, Lina; Sahebkar, Amirhossein; ... more authors ( Elsevier Inc. , 2023 , Article)
      Adipose tissue is now recognized as an endocrine organ that secretes bioactive molecules called adipokines. These biomolecules regulate key physiological functions, including insulin sensitivity, energy metabolism, appetite ...

    • Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 

      Rafael, Lozano; Fullman, Nancy; Mumford, John Everett; Knight, Megan; Barthelemy, Celine M; ... more authors ( Elsevier , 2020 , Article)
      BackgroundAchieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority ...

    • MicroRNA-mediated regulation of LDL receptor: biological and pharmacological implications. 

      Keshavarz, Reyhaneh; Reiner, Željko; Zengin, Gokhan; Eid, Ali H; Sahebkar, Amirhossein ( Europe PM , 2023 , Article)
      One of the main causes of atherosclerosis is a disruption in cellular cholesterol hemostasis. The low-density lipoprotein receptor (LDLR) is an important factor in maintaining cholesterol homeostasis by the receptor-mediated ...

    • Paradoxical effects of statins on endothelial and cancer cells: the impact of concentrations 

      Ahmadi, Yasin; Fard, Javad Khalili; Ghafoor, Dlzar; Eid, Ali H.; Sahebkar, Amirhossein ( Springer Nature , 2023 , Article)
      In addition to their lipid-lowering functions, statins elicit additional pleiotropic effects on apoptosis, angiogenesis, inflammation, senescence, and oxidative stress. Many of these effects have been reported in cancerous ...

    • The pharmaco-epigenetics of hypertension: a focus on microRNA 

      Yaacoub, Serge; Boudaka, Ammar; AlKhatib, Ali; Pintus, Gianfranco; Sahebkar, Amirhossein; ... more authors ( Springer Nature , 2024 , Article)
      Hypertension is a major harbinger of cardiovascular morbidity and mortality. It predisposes to higher rates of myocardial infarction, chronic kidney failure, stroke, and heart failure than most other risk factors. By 2025, ...

    • Pleiotropic properties of statins via angiogenesis modulation in cardiovascular disease 

      Fatemeh, Zahedipour; Butler, Alexandra E.; Eid, Ali H.; Sahebkar, Amirhossein ( Elsevier , 2022 , Article)
      Inhibition of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase by statins is affected by inhibiting the active site of the enzyme in a competitive manner. Statins reduce plasma cholesterol by inhibiting its de novo ...

    • Selective Activation of G protein-coupled Estrogen Receptor 1 Attenuates Atherosclerosis. 

      Eid, Ali; Sahebkar, Amirhossein; Haider, M Zulqarnein ( Bentham Science Publishers , 2023 , Article Review)
      Atherosclerosis remains a leading contributor to cardiovascular disease-associated morbidity and mortality. Interestingly, the death rate is higher in men than women from atherosclerosis, and the risk increases for ...

    • Therapeutic effects of statins on osteoarthritis: A review 

      Saberianpour, Shirin; Abolbashari, Samaneh; Modaghegh, Mohamad H.S.; Karimian, Maryam S.; Eid, Ali H.; ... more authors ( Wiley , 2022 , Article Review)
      Osteoarthritis (OA) is a progressive joint disease. The etiology of OA is considered to be multifactorial. Currently, there is no definitive treatment for OA, and the existing treatments are not very effective. ...