Browsing by Author "Nasser, Suzanne A."
Now showing items 1-13 of 13
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C-peptide in diabetes: A player in a dual hormone disorder?
Dakroub, Ali; Dbouk, Ali; Asfour, Aref; Nasser, Suzanne A.; El-Yazbi, Ahmed F.; Sahebkar, Amirhossein; Eid, Assaad A.; Iratni, Rabah; Eid, Ali H.... more authors ... less authors ( Wiley-Blackwell , 2024 , Article)C-peptide, a byproduct of insulin synthesis believed to be biologically inert, is emerging as a multifunctional molecule. C-peptide serves an anti-inflammatory and anti-atherogenic role in type 1 diabetes mellitus (T1DM) ... -
Cannabinoids and Myocardial Ischemia: Novel insights, Updated Mechanisms, and Implications for Myocardial Infarction
El Dahan, Karim Seif; Machtoub, Dima; Massoud, Gaelle; Nasser, Suzanne A.; Hamam, Bassam; Kobeissy, Firas; Zouein, Fouad A.; Eid, Ali H.... more authors ... less authors ( Bentham Science Publishers , 2022 , Article)Cannabis is the most widely trafficked and abused illicit drug due to its calming psychoactive properties. It has been increasingly recognized as having potential health benefits and relatively less adverse health effects ... -
Epac as a tractable therapeutic target
Hasan, Slika; Mansour, Hadi; Nasser, Suzanne A.; Shaito, Abdullah; Kobeissy, Firas; Orekhov, Alexander N.; Pintus, Gianfranco; Eid, Ali H.... more authors ... less authors ( Elsevier , 2023 , Article)In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing ... -
Estrogen and Bisphenol A in Hypertension
Wehbe, Zena; Nasser, Suzanne A.; El-Yazbi, Ahmed; Nasreddine, Salam; Eid, Ali H. ( Springer , 2020 , Article Review)Purpose of Review: Cardiovascular disease (CVD) is a non-subsiding disease that remains a leading cause of morbidity and mortality. CVD has been associated with endocrine disruptors, such as bisphenol A (BPA). This review ... -
Estrogen increases expression of vascular alpha 2C adrenoceptor through the cAMP/Epac/JNK/AP-1 pathway and potentiates cold-induced vasoconstriction
Fardoun, Manal M.; Issa, Khodr; Maaliki, Dina; Nasser, Suzanne A.; Baydoun, Elias; Eid, Ali H.... more authors ... less authors ( Elsevier , 2020 , Article)Cutaneous cold-induced vasoconstriction is a normal physiological reaction mediated by alpha 2C-adrenergic receptors (α2C-ARs) expressed in vascular smooth muscle cells (VSMCs). When this reaction is exaggerated, Raynaud's ... -
GPER Acts Through the cAMP/Epac/JNK/AP-1 Pathway to Induce Transcription of Alpha 2C Adrenoceptor in Human Microvascular Smooth Muscle Cells
Fardoun, Manal; Nasser, Suzanne A.; El-Yazbi, Ahmed F.; Eid, Ali H. ( Wolters Kluwer Health , 2023 , Article)Raynaud's phenomenon, which results from exaggerated cold-induced vasoconstriction, is more prevalent in females than males. We previously showed that estrogen increases the expression of alpha 2C-adrenoceptors (α2C-AR), ... -
Inflammation and hypertension: Underlying mechanisms and emerging understandings
Aboukhater, Diana; Morad, Bassel; Nasrallah, Nadim; Nasser, Suzanne A.; Sahebkar, Amirhossein; Kobeissy, Firas; Boudaka, Ammar; Eid, Ali H.... more authors ... less authors ( wiley online library , 2023 , Article Review)Hypertension remains a major contributor to cardiovascular disease (CVD), a leading cause of global death. One of the major insults that drive increased blood pressure is inflammation. While it is the body's defensive ... -
Inflammatory basis of atherosclerosis: Modulation by sex hormones
Nasser, Suzanne A.; Afify, Elham A.; Kobeissy, Firas; Hamam, Bassam; Eid, Ali H.; El-Mas, Mahmoud M.... more authors ... less authors ( Bentham Science Publishers , 2021 , Other)Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause of death globally. Several lines of evidence are supportive of the contributory role of vascular inflammation in atherosclerosis. Di-verse immune ... -
Mechanisms underlying the effects of caloric restriction on hypertension
Ahmad A., Al Attar; Fahed, Gracia I.; Hoballah, Malak M.; Pedersen, Shona; El-Yazbi, Ahmed F.; Nasser, Suzanne A.; Bitto, Alessandra; Orekhov, Alexander N.; Eid, Ali H.... more authors ... less authors ( Elsevier , 2022 , Article)Hypertension is a major risk factor for cardiovascular disease (CVD) as well as a major contributor to all-cause mortality and disability worldwide. The pathophysiology of hypertension is highly attributed to a dysfunctional ... -
Origanum syriacum L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells
AlKahlout, Amal; Fardoun, Manal; Mesmar, Joelle; Abdallah, Rola; Badran, Adnan; Nasser, Suzanne A.; Baydoun, Serine; Kobeissy, Firas; Shaito, Abdullah; Iratni, Rabah; Muhammad, Khalid; Baydoun, Elias; Eid, Ali H.... more authors ... less authors ( Frontiers Media , 2022 , Article)Breast cancer is the leading cause of cancer-related deaths among women. Among breast cancer types, triple negative breast cancer (TNBC) is the most aggressive, and is resistant to hormonal and chemotherapeutic treatments. ... -
The mitochondria: A target of polyphenols in the treatment of diabetic cardiomyopathy
Bhagani, Humna; Nasser, Suzanne A.; Dakroub, Ali; El-Yazbi, Ahmed F.; Eid, Assaad A.; Kobeissy, Firas; Pintus, Gianfranco; Eid, Ali H.... more authors ... less authors ( MDPI , 2020 , Article)Diabetic cardiomyopathy (DCM) is a constellation of symptoms consisting of ventricular dysfunction and cardiomyocyte disarray in the presence of diabetes. The exact cause of this type of cardiomyopathy is still unknown; ... -
Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms
Hasan, Slika; Mansour, Hadi; Wehbe, Nadine; Nasser, Suzanne A.; Iratni, Rabah; Nasrallah, Gheyath; Shaito, Abdullah; Ghaddar, Tarek; Kobeissy, Firas; Eid, Ali H.... more authors ... less authors ( Elsevier , 2022 , Article)Cancer is a leading cause of morbidity and mortality around the globe. Reactive oxygen species (ROS) play contradicting roles in cancer incidence and progression. Antioxidants have attracted attention as emerging therapeutic ... -
Visfatin : An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases
Dakroub, Ali; Nasser, Suzanne A; Kobeissy, Firas; Yassine, Hadi M; Orekhov, Alexander; Sharifi-Rad, Javad; Iratni, Rabah; El-Yazbi, Ahmed F; Eid, Ali H... more authors ... less authors ( Wiley , 2021 , Article)Visfatin/nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine expressed predominately in visceral fat tissues. High circulating levels of visfatin/NAMPT have been implicated in vascular remodeling, vascular ...