Browsing by Author "Haris, Mohammad"
Now showing items 21-33 of 33
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miRNAs as novel immunoregulators in cancer
Saife N., Lone; Bhat, Ajaz A.; Wani, Nissar A.; Karedath, Thasni; Hashem, Sheema; Nisar, Sabah; Singh, Mayank; Bagga, Puneet; Das, Bhudev Chandra; Bedognetti, Davide; Reddy, Ravinder; Frenneaux, Michael P.; El-Rifai, Wael; Siddiqi, Mushtaq A.; Haris, Mohammad; Macha, Muzafar A.... more authors ... less authors ( Elsevier , 2021 , Article Review)The immune system is a well-known vital regulator of tumor growth, and one of the main hallmarks of cancer is evading the immune system. Immune system deregulation can lead to immune surveillance evasion, sustained cancer ... -
RAS-mediated oncogenic signaling pathways in human malignancies
Khan, Abdul Q.; Kuttikrishnan, Shilpa; Kodappully S., Siveen; Kirti S., Prabhu; Shanmugakonar, Muralitharan; Al- Naemi, Hamda A.; Haris, Mohammad; Dermime, Said; Uddin, Shahab... more authors ... less authors ( Elsevier , 2018 , Article Review)Abnormally activated RAS proteins are the main oncogenic driver that governs the functioning of major signaling pathways involved in the initiation and development of human malignancies. Mutations in RAS genes and or its ... -
Role of animal research in human malignancies
Abdul Q., Khan; Siveen, Kodappully S.; Prabhu, Kirti S.; Kuttikrishnan, Shilpa; Akhtar, Sabah; Shanmugakonar, Muralitharan; Al-Naemi, Hamda A.; Haris, Mohammad; Uddin, Shahab... more authors ... less authors ( Elsevier , 2019 , Book chapter)Animal models are the central backbone in relation to providing the safety information of xenobiotics, the nature of chemicals present in the environment, and understanding the developmental process in disease pathogenesis ... -
Role of NAD+ in regulating cellular and metabolic signaling pathways
Sara, Amjad; Nisar, Sabah; Bhat, Ajaz A.; Shah, Ab Rauf; Frenneaux, Michael P.; Fakhro, Khalid; Haris, Mohammad; Reddy, Ravinder; Patay, Zoltan; Baur, Joseph; Bagga, Puneet... more authors ... less authors ( Elsevier , 2021 , Article Review)BackgroundNicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in every living cell, is involved in a myriad of metabolic processes associated with cellular bioenergetics. For this reason, NAD+ is often ... -
Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance.
Bhat, Ajaz A; Younes, Salma N; Raza, Syed Shadab; Zarif, Lubna; Nisar, Sabah; Ahmed, Ikhlak; Mir, Rashid; Kumar, Sachin; Sharawat, Surender K; Hashem, Sheema; Elfaki, Imadeldin; Kulinski, Michal; Kuttikrishnan, Shilpa; Prabhu, Kirti S; Khan, Abdul Q; Yadav, Santosh K; El-Rifai, Wael; Zargar, Mohammad A; Zayed, Hatem; Haris, Mohammad; Uddin, Shahab... more authors ... less authors ( BMC , 2020 , Article Review)Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia ... -
Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway
Kirti.S., Prabhu; Bhat, Ajaz A.; Siveen, Kodappully S.; Kuttikrishnan, Shilpa; Raza, Syed Shadab; Raheed, Thesni; Jochebeth, Anh; Khan, Abdul Q.; Chawdhery, M.Zafar; Haris, Mohammad; Kulinski, Michal; Dermime, Said; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( Elsevier , 2021 , Article)Effective treatment of lung cancer remains a significant clinical challenge due to its multidrug resistance and side effects of the current treatment options. The high mortality associated with this malignancy indicates ... -
Single-Voxel H MR spectroscopy of cerebral nicotinamide adenine dinucleotide (NAD ) in humans at 7T using a 32-channel volume coil.
Bagga, Puneet; Hariharan, Hari; Wilson, Neil E; Beer, Joanne C; Shinohara, Russell T; Elliott, Mark A; Baur, Joseph A; Marincola, Francesco M; Witschey, Walter R; Haris, Mohammad; Detre, John A; Reddy, Ravinder... more authors ... less authors ( Wiley , 2019 , Article)Reliable monitoring of tissue nicotinamide adenine dinucleotide (NAD ) concentration may provide insights on its roles in normal and pathological aging. In the present study, we report a H MRS pulse sequence for the in ... -
Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents
Sheema, Hashem; Ali, Tayyiba Akbar; Akhtar, Sabah; Nisar, Sabah; Sageena, Geetanjali; Ali, Shahid; Al-Mannai, Sharefa; Therachiyil, Lubna; Mir, Rashid; Elfaki, Imadeldin; Mir, Mohammad Muzaffar; Jamal, Farrukh; Masoodi, Tariq; Uddin, Shahab; Singh, Mayank; Haris, Mohammad; Macha, Muzafar; Bhat, Ajaz A.... more authors ... less authors ( Elsevier , 2022 , Article Review)Cancer is one of the leading causes of death and significantly burdens the healthcare system. Due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. The use of natural products as ... -
Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk.
Bhat, Ajaz A; Uppada, Srijayaprakash; Achkar, Iman W; Hashem, Sheema; Yadav, Santosh K; Shanmugakonar, Muralitharan; Al-Naemi, Hamda A; Haris, Mohammad; Uddin, Shahab... more authors ... less authors ( Frontiers Media , 2019 , Article)The ability of epithelial cells to organize through cell-cell adhesion into a functioning epithelium serves the purpose of a tight epithelial protective barrier. Contacts between adjacent cells are made up of tight junctions ... -
The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities
Mehraj, Umar; Ganai, Rais A.; Macha, Muzafar A.; Hamid, Abid; Zargar, Mohammed A.; Bhat, Ajaz A.; Nasser, Mohd Wasim; Haris, Mohammad; Batra, Surinder K.; Alshehri, Bader; Al-Baradie, Raid Saleem; Mir, Manzoor A.; Wani, Nissar Ahmad... more authors ... less authors ( Springer , 2021 , Article Review)Background: Breast cancer (BC), the second most common cause of cancer-related deaths, remains a significant threat to the health and wellness of women worldwide. The tumor microenvironment (TME), comprising cellular ... -
Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy.
Bhat, Ajaz A; Yousuf, Parvaiz; Wani, Nissar A; Rizwan, Arshi; Chauhan, Shyam S; Siddiqi, Mushtaq A; Bedognetti, Davide; El-Rifai, Wael; Frenneaux, Michael P; Batra, Surinder K; Haris, Mohammad; Macha, Muzafar A... more authors ... less authors ( Springer Nature , 2021 , Article Review)Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have revealed the highly heterogeneous and ... -
Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells.
Chauhan, Ravi; Bhat, Ajaz A; Masoodi, Tariq; Bagga, Puneet; Reddy, Ravinder; Gupta, Ashna; Sheikh, Zahoor Ahmad; Macha, Muzafar A; Haris, Mohammad; Singh, Mayank... more authors ... less authors ( BMC , 2021 , Article Review)Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins involved in homeostatic cellular function. Inconsistencies in the ... -
A Whole-Genome Sequencing Association Study of Low Bone Mineral Density Identifies New Susceptibility Loci in the Phase I Qatar Biobank Cohort.
Younes, Nadin; Syed, Najeeb; Yadav, Santosh K; Haris, Mohammad; Abdallah, Atiyeh M; Abu-Madi, Marawan... more authors ... less authors ( MDPI , 2021 , Article)Bone density disorders are characterized by a reduction in bone mass density and strength, which lead to an increase in the susceptibility to sudden and unexpected fractures. Despite the serious consequences of low bone ...