السجلات المعروضة 1 -- 20 من 48
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A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country
( Springer Science and Business Media Deutschland GmbH , 2022 , Article)Background: Sodium glucose co-transporter 2 inhibitors (SGLT2is) are a novel class of oral antidiabetic drugs. To date, there are no pharmacoepidemiologic studies investigating the pattern of use of SGLT2is compared to ... -
A Review of Pharmacogenetics of Antimalarials and Associated Clinical Implications
( Springer-Verlag France , 2017 , Article Review)Genetic variability in drug-metabolizing enzymes and drug transporters is known to influence the pharmacokinetics of many drugs. Antimalarial drugs are a class of agents known to utilize metabolic and elimination pathways ... -
A survey on the awareness and attitude of pharmacists and doctors towards the application of pharmacogenomics and its challenges in Qatar
( John Wiley & Sons, Ltd. , 2015 , Article)RATIONALE, AIMS AND OBJECTIVES: Pharmacists are expected to play an important role in applying pharmacogenomics discoveries to patient care. Despite the increased attention to genetic research in Qatar, clinicians' attitudes ... -
Anticoagulation clinic drive-up service during COVID-19 pandemic in Qatar
( Springer , 2021 , Article)Coronavirus Disease 2019 (COVID-19) is a pandemic affecting many countries worldwide. Given the increasing incidence especially in elderly and individuals with comorbid conditions, it is advised by health authorities to ... -
Assessing Pharmacists Knowledge and Attitude Toward the Direct Oral Anticoagulants in Qatar
( SAGE Publications Inc. , 2020 , Article)Pharmacists were found to play a key role in anticoagulation care. In order to make an appropriate selection and counselling regarding direct oral anticoagulants (DOACs), pharmacists should be knowledgeable and abiding by ... -
Assessment of the attitude, awareness and practice of periprocedural warfarin management among health care professional in Qatar. A cross sectional survey
( Springer , 2020 , Article)It is estimated that 10–15% of oral anticoagulant (OAC) patients, would need to hold their OAC for scheduled surgery. Especially for warfarin, this process is complex and requires multi-layer risk assessment and decisions ... -
Bridging vs Non-Bridging with Warfarin Peri-Procedural Management: Cost and Cost-Effectiveness Analyses
( Elsevier , 2021 , Article)The warfarin peri-procedural management in Qatar is predominantly based on bridging (63%), compared to non-bridging. This study sought to perform a first-time cost analysis of current warfarin peri-procedural management ... -
Cancer-Associated Venous Thromboembolism
( Springer Healthcare , 2016 , Article Review)Cancer patients are at high risk for venous thromboembolism (VTE) which is considered the second leading cause of death among this population. Both cancer and cancer treatment increase this risk. Since the risk of VTE is ... -
Cisplatin-induced ototoxicity: A novel approach to an ancient problem
( Lippincott, Williams & Wilkins , 2023 , Article)With the scarcity of pharmacological otoprotective agents against cisplatin-induced ototoxicity (CIO), researchers find themselves compelled to look at and navigate all possible strategies to identify ways to prevent CIO. ... -
Comparative effectiveness and safety of direct oral anticoagulants compared to warfarin in morbidly obese patients with acute venous thromboembolism: systematic review and a meta-analysis
( Springer , 2021 , Article)Direct oral anticoagulant (DOAC) agents are becoming the anticoagulation strategy of choice. However, their use in the treatment of acute venous thromboembolism (VTE) in morbidly obese patients (bodyweight of > 120 kg or ... -
Cost-Benefit Analysis of Genotype-Guided Interruption Days in Warfarin Pre-Procedural Management
( Elsevier , 2022 , Article)Warfarin is commonly used in thromboembolic conditions. Warfarin interruption represents a significant challenge in pre-operative warfarin management as it is associated with major consequences. Genetics polymorphism ... -
The design and implementation of an undergraduate health professional degree elective course on scientific writing, peer assessment, and critical appraisal
( Elsevier , 2022 , Other)Background and purpose: Strong writing skills are critical to the pharmacy profession. This paper describes the design, delivery, and impact of a course intended to develop pharmacy students' scientific writing, peer ... -
Direct oral anticoagulants are effective and safe in the treatment of venous thromboembolism and atrial fibrillation in morbidly obese patients
( Springer , 2020 , Other)There has always been unresolved uncertainty regarding the therapeutic utility of direct oral anticoagulants (DOACs) in morbidly obese patients (BMI > 40 kg/m2 or weight > 120 kg) with clinical indications for anticoagulant's ... -
Drive-up INR testing and phone-based consultations service during COVID-19 pandemic in a pharmacist-lead anticoagulation clinic in Qatar: Monitoring, clinical, resource utilization, and patient- oriented outcomes
( Wiley , 2021 , Article)Background: Coronavirus disease 2019 (COVID-19) pandemic has resulted in unprecedented pressure on healthcare systems and led to widespread utilization of telemedicine or telehealth services. Combined with teleclinics, ... -
Economic Evaluation of CYP2C19 Genotype-Guided Antiplatelet Therapy Compared to Universal Use of Ticagrelor or Clopidogrel in Qatar
( Qatar University Press , 2020 , Poster)Background: Patients having CYP2C19 loss-of-function alleles and receiving clopidogrel are at higher risk of adverse cardiovascular outcomes. Ticagrelor is a more effective and expensive antiplatelet that is unaffected by ... -
Economic Evaluations of CYP2C19 Genotype-Guided Antiplatelet Therapy Compared to the Universal Use of Antiplatelets in Patients With Acute Coronary Syndrome: A Systematic Review.
( SAGE Publications , 2020 , Article)Clopidogrel is widely used after the percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) and requires activation by cytochrome P450 (CYP), primarily CYP2C19. Patients with CYP2C19 ... -
Effect of CYP2C19 genetic variants on bleeding and major adverse cardiovascular events in a cohort of Arab patients undergoing percutaneous coronary intervention and stent implantation
( Lippincott Williams and Wilkins , 2022 , Article)Introduction One-third of patients have clopidogrel resistance that may lead to major adverse cardiac events (MACEs). By contrast, it was found that some clopidogrel-treated patients have hyperresponsive platelets that are ... -
The effect of genetic and nongenetic factors on warfarin dose variability in Qatari population.
( Pharmacogenomics Journal , 2020 , Article)The objective of this study is to estimate the prevalence of VKORC1, CYP2C9, and CYP4F2 genetic variants and their contribution to warfarin dose variability in Qataris. One hundred and fifty warfarin-treated Qatari patients ... -
Effect of Pharmacogenetic-Based Decision Support Tools in Improving Depression Outcomes: A Systematic Review
( Qatar University Press , 2021 , Poster)Introduction: Evidence supporting pharmacogenetic (PGX) tests utility in depression is scarce. The main objectives of this study were to summarize, update, and assess the quality of the available evidence regarding PGX ... -
Effect of pharmacogenetic-based decision support tools in improving depression outcomes: A systematic review
( Taylor & Francis Group , 2021 , Other)Objective: Evidence supporting the utility of pharmacogenetic (PGX) tests in depression is scarce. The main objectives of this study were to summarize, update, and assess the quality of the available evidence regarding PGX ...
