Browsing by Author "Elewa, Hazem"
Now showing items 21-40 of 48
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Effect of SAMe-TT2R2 score and genetic polymorphism on the quality of anticoagulation control in Qatari patients treated with warfarin.
Elewa, Hazem; Qurishi, Iqrah; Abouelhassan, Rawan; Abou Safrah, Salam; Alhamoud, Eman; Bader, Loulia... more authors ... less authors ( Springer Nature , 2020 , Article)There is no strong evidence on pharmacogenetics role on the quality of INR control after the initiation phase and on the maintenance of stable INR on the long term as measured by the time in therapeutic range (TTR). The ... -
Evaluation of pharmacist-based compared to doctor-based anticoagulation management in Qatar
Elewa, Hazem; Jalali, Fatemeh; Khudair, Nada; Hassaballah, Noha; Abdelsamad, Osama; Mohammed, Shaban... more authors ... less authors ( Blackwell Publishing Ltd , 2016 , Article)Rationale, aims and objectives For over 60 years, warfarin has been the mainstay anticoagulant used in the outpatient setting for the prevention and treatment of a wide variety of thromboembolic clinical conditions. ... -
Evaluation of the Validity of SAMe-TT2R2 Score in a Cohort of Venous Thromboembolism Patients Treated With Warfarin
Alhmoud, Eman Nawash; Elewa, Hazem; Abdul Gelil, Mohammed S.; Abd El Samad, Osama B.; Elzouki, Abdelnasser Y. ( SAGE Publications Inc. , 2020 , Article)Low SAMe-TT2R2 score of <2 was validated as a predictor of optimum anticoagulation control, reflected by mean time in therapeutic range (TTR) above 65% to 70%, among warfarin-treated atrial fibrillation patients. This study ... -
Exploring the Influence of Language on Assessment Given a Mismatch Between Language of Instruction and Language of Practice
Diab, Mohammad I; Nasr, Ziad G; El-Hajj, Maguy S; Elewa, Hazem; El-Geed, Hager A; Wilby, Kyle John... more authors ... less authors ( Lippincott, Williams & Wilkins , 2019 , Article)A phenomenon is occurring in international settings where the language of program delivery and assessment does not match the primary language of practice. It is unknown whether determining competence in English disadvantages ... -
Genetic and non-genetic factors impact on inr normalization in preprocedural warfarin management
Eljilany, Islam; Elarref, Mohamed; Shallik, Nabil; Elzouki, Abdel Naser; Bader, Loulia; El-Bardissy, Ahmed; Abdelsamad, Osama; Al-Badriyeh, Daoud; Cavallari, Larisa H.; Elewa, Hazem... more authors ... less authors ( Dove Medical Press , 2021 , Article)Background: Annually, 10% of warfarin patients will likely need to stop warfarin prior to elective surgery to achieve a baseline international normalization ratio (INR) level (INR ≤ 1.2) at the time of the procedure. This ... -
Genetic polymorphism effect on warfarin–rifampin interaction: A case report and review of literature
Salem, Muhammad; Eljilany, Islam; El-Bardissy, Ahmed; Elewa, Hazem ( Dove Medical Press , 2021 , Article)Warfarin–rifampin interaction has been reported since the 1970s. Due to rifampin’s strong induction of CYP2C9, most cases could not attain the target international normalized ratio (INR) despite warfarin dose escalation. ... -
Genomewide association analysis of warfarin dose requirements in Middle Eastern and North African populations
El Rouby, Nihal; Shahin, Mohamed H.; Bader, Loulia; Khalifa, Sherief I.; Elewa, Hazem ( Wiley-Blackwell , 2022 , Article)To date, there has been no genomewide association study (GWAS) from the Middle East and North African (MENA) region to identify genetic variants associated with warfarin dose variability using this approach. In this study, ... -
Impact of Genetic Polymorphisms on Phenytoin Pharmacokinetics and Clinical Outcomes in the Middle East and North Africa Region
Dagenais, Renée; Wilby, Kyle John; Elewa, Hazem; Ensom, Mary H.H. ( Springer International Publishing , 2017 , Article Review)Background Genetic polymorphisms are known to influence outcomes with phenytoin yet effects in the Middle East and North Africa region are poorly understood. Objectives The objective of this systematic review was to ... -
Periprocedural Anticoagulation Management of Patients receiving Warfarin in Qatar: A Prospective Cohort Study
Eljilany, Islam; Elarref, Mohamed; Shallik, Nabil; Elzouki, Abdel-Naser; Mohammed, AbdulMoqeeth; Shoman, Bassam; Ibrahim, Sami; Carr, Cornelia; Al-Badriyeh, Daoud; Cavallari, Larisa H.; Elewa, Hazem... more authors ... less authors ( Elsevier , 2021 , Article)Background: The use of anticoagulant bridging remains controversial. This study was conducted to evaluate our warfarin periprocedural management in Qatar and investigate the associated clinical outcomes with such management. ... -
Pharmacogenomics In Pharmacy Practice: Current Perspectives.
Elewa, Hazem; Awaisu, Ahmed ( Dove Medical Press , 2019 , Article)Pharmacogenomics (i.e., the application of genetic information in predicting an individual's response to drug therapy) plays an increasingly important role in drug development and decision-making regarding precision medicine. ... -
Potential Therapeutic Effects of Sodium Glucose-linked Cotransporter 2 Inhibitors in Stroke
Al Hamed, Fatima Alzahra; Elewa, Hazem ( Elsevier , 2020 , Article Review)Purpose: Stroke is the second leading cause of death and the third leading cause of disability worldwide. Diabetes mellitus and the associated hyperglycemia are important risk factors for acute ischemic stroke and are ... -
Preemptive Dose Adjustment Effect on the Quality of Anticoagulation Management in Warfarin Patients With Drug Interactions: A Retrospective Cohort Study
Fahmi, Amr Mohamed; Mohamed, Adham; Elewa, Hazem; Saad, Mohamed Omar ( SAGE Publications Inc. , 2019 , Article)One strategy to manage patients on warfarin starting an interacting drug is to increase the frequency of monitoring. Another strategy is to adjust warfarin dose around the time patient is started on an interacting medication, ... -
Prevalence of Venous Thromboembolism in Critically Ill COVID-19 Patients: Systematic Review and Meta-Analysis
Mohamed, Mouhand F.H.; Al-Shokri, Shaikha D.; Shunnar, Khaled M.; Mohamed, Sara F.; Najim, Mostafa S.; Ibrahim, Shahd I.; Elewa, Hazem; Abdalla, Lina O.; El-Bardissy, Ahmed; Elshafei, Mohamed Nabil; Abubeker, Ibrahim Y.; Danjuma, Mohammed; Dousa, Khalid M.; Yassin, Mohamed A.... more authors ... less authors ( Frontiers Media S.A. , 2021 , Article)Background: Recent studies revealed a high prevalence of venous thromboembolism (VTE) events in coronavirus disease 2019 (COVID-19) patients, especially in those who are critically ill. Available studies report varying ... -
Rifampin-warfarin interaction in a mitral valve replacement patient receiving rifampin for infective endocarditis: a case report
Fahmi, Amr Mohamed; Abdelsamad, Osama; Elewa, Hazem ( SpringerOpen , 2016 , Article)Warfarin therapy is associated with many drug interactions that may cause a significant alteration in its anticoagulant effect. Rifampin is a widely used antimicrobial that has major interactions with several medications ... -
Short- and long-term cost-effectiveness analysis of CYP2C19 genotype-guided therapy, universal clopidogrel, versus universal ticagrelor in post-percutaneous coronary intervention patients in Qatar
Sawsan, AlMukdad; Elewa, Hazem; Arafa, Salaheddin; Al-Badriyeh, Daoud ( Elsevier , 2021 , Article)BackgroundPatients having CYP2C19 loss-of-function alleles and receiving clopidogrel are at higher risk of adverse cardiovascular outcomes. Ticagrelor is an effective antiplatelet that is unaffected by the CYP2C19 polymorphism. ... -
Strategies to Optimize Dual Antiplatelet Therapy after Coronary Artery Stenting in Acute Coronary Syndrome
Paravattil, Bridget; Elewa, Hazem ( SAGE Publications Ltd , 2017 , Article)The use of aspirin and a P2Y12 receptor antagonist as dual antiplatelet therapy (DAPT) has become the treatment of choice in patients with acute coronary syndrome (ACS) and percutaneous coronary intervention to prevent ... -
Survey Among Healthcare Professionals On The Implications Of Pharmacogenetics And Its Limitations
Alkhiyami, Dania; Alsahan, Dima; Abdelbari, Ahmed; Elewa, Hazem ( Hamad bin Khalifa University Press (HBKU Press) , 2014 , Conference Paper)Pharmacists are expected to play an important role in applying pharmacogenetic discoveries to patient care. Despite the increased attention to genetic research in Qatar, clinicians' attitude towards pharmacogenetics' ... -
Telephone versus office-based management of warfarin: Impact on international normalized ratios and outcomes
Stoudenmire, Laura G.; DeRmer, Christina E.; Elewa, Hazem ( Springer-Verlag Tokyo , 2014 , Article)Studies have concluded that telephone-based management of warfarin is an effective alternative to in-office management. High rates of patient and physician satisfaction have been reported with telephone-based monitoring. ... -
The Dilemma of Peri-Procedural Warfarin Management: A Narrative Review
Eljilany, Islam; El-Bardissy, Ahmed; Elewa, Hazem ( SAGE Publications Inc. , 2021 , Article Review)Periprocedural vitamin K antagonist management is a complex process and inherently entails multiple clinical issues. Marked variations have been reported in different aspects of this process. These differences were noted ... -
The Effect of CYP2C19 and Nongenetic Factors on Clopidogrel Responsiveness in the MENA Region: A Systematic Review
Ali, Zainab; Elewa, Hazem ( SAGE Publications Inc. , 2019 , Article Review)Clopidogrel is the cornerstone antiplatelet used in the treatment and prevention of thrombotic events. Some studies examined the effect of CYP2C19 polymorphism and nongenetic factors on clopidogrel response in the Middle ...