Browsing by Author "Akhtar S."
Now showing items 1-10 of 10
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Curcumin-mediated degradation of S-phase kinase protein 2 induces cytotoxic effects in human papillomavirus-positive and negative squamous carcinoma cells
Khan A.Q.; Siveen K.S.; Prabhu K.S.; Kuttikrishnan S.; Akhtar S.; Shaar A.; Raza A.; Mraiche F.; Dermime S.; Uddin S.... more authors ... less authors ( Frontiers Media S.A. , 2018 , Article)S-phase kinase-associated protein2 (Skp2), a proto-oncoprotein, plays an important role in development and progression of human malignancies. Skp2 is frequently overexpressed in many human malignancies. It targets cell ... -
In honour of Professor Jackie Ying, recipient of the Journal of Drug Targeting's Lifetime Achievement Award�for 2020
Akhtar S. ( Taylor and Francis Ltd , 2020 , Article)[No abstract available] -
In honour of Professor Leaf Huang, recipient of the Journal of Drug Targeting's life-time achievement award for 2018
Akhtar S. ( Taylor and Francis Ltd , 2018 , Article)[No abstract available] -
In honour of Professor Patrick Couvreur, recipient of the Journal Of Drug Targeting?s Lifetime Achievement Award For 2019
Akhtar S. ( Taylor and Francis Ltd , 2019 , Article)[No abstract available] -
In honour of Professor Patrick Couvreur, recipient of the Journal Of Drug Targeting’s Lifetime Achievement Award For 2019
Akhtar S. ( Taylor and Francis Ltd , 2019 , Other)[No abstract available] -
Is there truly an increase in risk of cardiovascular and hematological adverse events with vascular endothelial growth factor receptor tyrosine kinase inhibitors?
Furuya-Kanamori L.; Doi S.A.; Onitilo A.; Akhtar S. ( Taylor and Francis Ltd , 2020 , Article)Objectives: Recent studies have shown an increase risk of cardiovascular and hematological adverse events associated with vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs). The authors hypothesize ... -
Nanotoxicology of dendrimers in the mammalian heart: Ex vivo and in vivo administration of g6 pamam nanoparticles impairs recovery of cardiac function following ischemia-reperfusion injury
Babiker F.; Benter I.F.; Akhtar S. ( Dove Medical Press Ltd. , 2020 , Article)Aim: The effects of polyamidoamine (PAMAM) dendrimers on the mammalian heart are not completely understood. In this study, we have investigated the effects of a sixth-generation cationic dendrimer (G6 PAMAM) on cardiac ... -
Pharmacotherapy in COVID-19 patients: a review of ACE2-raising drugs and their clinical safety
Akhtar, S.; Benter, I.F.; Danjuma, M.I.; Doi, S.A.R.; Hasan, S.S.; Habib, A.M.... more authors ... less authors ( Taylor and Francis Ltd , 2020 , Article Review)The COVID-19 pandemic is caused by the severe acute-respiratory-syndrome-coronavirus-2 that uses ACE2 as its receptor. Drugs that raise serum/tissue ACE2 levels include ACE inhibitors (ACEIs) and angiotensin-II receptor ... -
Sanguinarine suppresses growth and induces apoptosis in childhood acute lymphoblastic leukemia
Kuttikrishnan S.; Siveen K.S.; Prabhu K.S.; Khan A.Q.; Akhtar S.; Mateo J.M.; Merhi M.; Taha R.; Omri H.E.; Mraiche F.; Dermime S.; Uddin S.... more authors ... less authors ( Taylor and Francis Ltd , 2019 , Article)Sanguinarine (Sang), a plant-derived compound isolated from the roots of Sanguinaria canadensis was evaluated for its potential pro-apoptotic effects in precursor B acute lymphoblastic leukemia (Pre-ALL) cell lines. Treatment ... -
The Role of Epidermal Growth Factor Receptor Family of Receptor Tyrosine Kinases in Mediating Diabetes-Induced Cardiovascular Complications
Shraim B.A.; Moursi M.O.; Benter I.F.; Habib A.M.; Akhtar S. ( Frontiers Media S.A. , 2021 , Article)Diabetes mellitus is a major debilitating disease whose global incidence is progressively increasing with currently over 463 million adult sufferers and this figure will likely reach over 700 million by the year 2045. It ...