Browsing by Author "Malki, A."
Now showing items 1-5 of 5
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“Breakthrough Therapies” for Breast Cancer Metastasis.
Malki, A; Mohsen, M; Aziz, H ( OMICS International , 2015 , Article)Breast Cancer Metastasis (MBC) is an ultimate death sentence remains a challenge for clinicians worldwide.According to the Metastatic Breast Cancer (MBC) Awareness Network about 155,000 patients are living nowadays with ... -
Design and synthesis of novel thioethers derived from 1,5-diphenyl-6-thioxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones as antiangiogenic agents
Malki, A.; Issa, D.A.E.; Elbayaa, R.Y.; Ashour, H.M.A. ( Bentham , 2018 , Article)Background: In attempts to discover new antiangiogenic entities, a novel series of thioethers derived from 6-thioxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidine-4(5H)ones was considered and designed. Methods: Virtual screening ... -
Epstein-Barr virus-associated malignancies: Roles of viral oncoproteins in carcinogenesis
El-Sharkawy A.; Al Zaidan L.; Malki A. ( Frontiers Media S.A. , 2018 , Article Review)The Epstein-Barr virus (EBV) is the first herpesvirus identified to be associated with human cancers known to infect the majority of the world population. EBV-associated malignancies are associated with a latent form of ... -
Glucose- and triglyceride-lowering dietary penta-O-galloyl-α-D-glucose reduces expression of PPARγ and C/EBPα, induces p21-Mediated G1 phase cell cycle arrest, and inhibits adipogenesis in 3T3-L1 preadipocytes
Liu, X.; Malki, A.; Cao, Y.; Li, Y.; Qian, Y.; Wang, X.; Chen, X.... more authors ... less authors ( Thieme , 2015 , Article)Plant polyphenols, such as hydrolysable tannins, are present in the human diet and known to exhibit anti-diabetic and anti-obesity activity. We previously reported that the representative hydrolysable tannin compound ... -
In vitro and in vivo efficacy of a novel quinuclidinone derivative against breast cancer
Malki, A.; Malki, Ahmed; El Ashry, El Sayed ( International Institute of Anticancer Research , 2014 , Other)Previously, our laboratory reported on novel quinuclidinone derivatives that cause cytotoxicity in human non-small lung carcinoma epithelial cells null for p53 (H1299). The current study aims to investigate the effect of ...