تصفح حسب المؤلف "Sankar, Srivarshini"
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Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach.
Udhaya Kumar, S; Thirumal Kumar, D; Bithia, R; Sankar, Srivarshini; Magesh, R.; Sidenna, Mariem; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Frontiers Media , 2020 , Article)Familial hypercholesterolemia (FH) is one of the major risk factor for the progression of atherosclerosis and coronary artery disease. This study focused on identifying the dysregulated molecular pathways and core genes ... -
Comprehensive in silico screening and molecular dynamics studies of missense mutations in Sjogren-Larsson syndrome associated with the ALDH3A2 gene.
Udhaya Kumar, S; Thirumal Kumar, D; Mandal, Pinky D; Sankar, Srivarshini; Haldar, Rishin; Kamaraj, Balu; Walter, Charles Emmanuel Jebaraj; R, Siva; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Elsevier , 2020 , Article)Sjögren-Larsson syndrome (SLS) is an autoimmune disorder inherited in an autosomal recessive pattern. To date, 80 missense mutations have been identified in association with the Aldehyde Dehydrogenase 3 Family Member A2 ... -
Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach.
S, Udhaya Kumar; Sankar, Srivarshini; Younes, Salma; D, Thirumal Kumar; Ahmad, Muneera Naseer; Okashah, Sarah Samer; Kamaraj, Balu; Al-Subaie, Abeer Mohammed; C, George Priya Doss; Zayed, Hatem... more authors ... less authors ( MDPI , 2020 , Article)Filamins (FLN) are a family of actin-binding proteins involved in regulating the cytoskeleton and signaling phenomenon by developing a network with F-actin and FLN-binding partners. The FLN family comprises three conserved ... -
Molecular dynamics, residue network analysis, and cross-correlation matrix to characterize the deleterious missense mutations in GALE causing galactosemia III.
Kumar, S Udhaya; Sankar, Srivarshini; Kumar, D Thirumal; Younes, Salma; Younes, Nadin; Siva, R; Doss, C George Priya; Zayed, Hatem... more authors ... less authors ( Springer , 2021 , Article)Epimerase-deficiency galactosemia (EDG) is caused by mutations in the UDP-galactose 4'-epimerase enzyme, encoded by gene GALE. Catalyzing the last reaction in the Leloir pathway, UDP-galactose-4-epimerase catalyzes the ...