تصفح حسب المؤلف "nr 98036333"
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High–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines
Rinchai, Darawan; Deola, Sara; Zoppoli, Gabriele; Kabeer, Basirudeen Syed Ahamed; Taleb, Sara; Pavlovski, Igor; Maacha, Selma; Gentilcore, Giusy; Toufiq, Mohammed; Mathew, Lisa; Liu, Li; Vempalli, Fazulur Rehaman; Mubarak, Ghada; Lorenz, Stephan; Sivieri, Irene; Cirmena, Gabriella; Dentone, Chiara; Cuccarolo, Paola; Giacobbe, Daniele Roberto; Baldi, Federico; Garbarino, Alberto; Cigolini, Benedetta; Cremonesi, Paolo; Bedognetti, Michele; Ballestrero, Alberto; Bassetti, Matteo; Hejblum, Boris P.; Augustine, Tracy; Van Panhuys, Nicholas; Thiebaut, Rodolphe; Branco, Ricardo; Chew, Tracey; Shojaei, Maryam; Short, Kirsty; Feng, Carl G.; Zughaier, Susu M.; De Maria, Andrea; Tang, Benjamin; Hssain, Ali Ait; Bedognetti, Davide; Grivel, Jean Charles; Chaussabel, Damien... more authors ... less authors ( American Association for the Advancement of Science , 2022 , Article)Knowledge of the mechanisms underpinning the development of protective immunity conferred by mRNA vaccines is fragmentary. Here, we investigated responses to coronavirus disease 2019 (COVID-19) mRNA vaccination via ... -
Real-Time SARS-CoV-2 Genotyping by High-Throughput Multiplex PCR Reveals the Epidemiology of the Variants of Concern in Qatar
R. Hasan, Mohammad; K.R. Kalikiri, Mahesh; Mirza, Faheem; Sundararaju, Sathyavathi; Sharma, Anju; Xaba, Thabisile; Lorenz, Stephan; Chemaitelly, Hiam; A. El-Kahlout, Reham; Ming Tsui, Kin; M. Yassine, Hadi; V. Coyle, Peter; Al Khal, Abdullatif; Bertollini, Roberto; H. Al Thani, Mohamed; J. Abu-Raddad, Laith; Tang, Patrick... more authors ... less authors ( Elsevier , 2021 , Article)Complementing whole genome sequencing strategies with high-throughput multiplex RT-qPCR genotyping allows for more comprehensive and real-time tracking of SARS-CoV-2 variants of concern. During the second and third waves ... -
Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes
Razali, Rozaimi Mohamad; Rodriguez-Flores, Juan; Ghorbani, Mohammadmersad; Naeem, Haroon; Aamer, Waleed; Aliyev, Elbay; Jubran, Ali; Ismail, Said I.; Al-Muftah, Wadha; Badji, Radja; Mbarek, Hamdi; Darwish, Dima; Fadl, Tasnim; Yasin, Heba; Ennaifar, Maryem; Abdellatif, Rania; Alkuwari, Fatima; Alvi, Muhammad; Al-Sarraj, Yasser; Saad, Chadi; Althani, Asmaa; Fethnou, Eleni; Qafoud, Fatima; Alkhayat, Eiman; Afifi, Nahla; Tomei, Sara; Liu, Wei; Lorenz, Stephan; Syed, Najeeb; Almabrazi, Hakeem; Vempalli, Fazulur Rehaman; Temanni, Ramzi; Saqri, Tariq Abu; Khatib, Mohammedhusen; Hamza, Mehshad; Zaid, Tariq Abu; El Khouly, Ahmed; Pathare, Tushar; Poolat, Shafeeq; Al-Ali, Rashid; Albagha, Omar; Al-Khodor, Souhaila; Alshafai, Mashael; Badii, Ramin; Chouchane, Lotfi; Estivill, Xavier; Fakhro, Khalid A.; Mokrab, Younes; Puthen, Jithesh V.; Suhre, Karsten; Tatari, Zohreh; Clark, Andrew G.... more authors ... less authors ( Nature Research , 2021 , Article)Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries ... -
Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model
Da’as, Sahar Isa; Hasan, Waseem; Salem, Rola; Younes, Nadine; Abdelrahman, Doua; Mohamed, Iman A.; Aldaalis, Arwa; Temanni, Ramzi; Mathew, Lisa Sara; Lorenz, Stephan; Yacoub, Magdi; Nomikos, Michail; Nasrallah, Gheyath K.; Fakhro, Khalid A.... more authors ... less authors ( MDPI , 2022 , Article)Variants in cardiac myosin-binding protein C (cMyBP-C) are the leading cause of inherited hypertrophic cardiomyopathy (HCM), demonstrating the key role that cMyBP-C plays in the heart’s contractile machinery. To investigate ...