Synthesis Of Some Glycyrrhetic Acid Sulfonamide Derivatives With Prospected Antimicrobial Activity

Abstract

Some glycyrrhetic acid sulfonamide derivatives (I-VIII) were prepared. Apart from their chemical structures which were confirmed by elemental analysis, IR, 'H and ^C-NMR, their behaviour under electron impact was also investigated; their antimicrobial activity was studied in comparison with 3 p-acetoxy glycyrrhetic acid chloride (A), parent sulfa drugs (1-8) and the solvent used (propylene glycol). It was noticed that the prepared sulfonamide derivatives (I-VIII) gave activity against Gram positive bacteria (Staphylococcus aureus; Bacillus antherasis and Crynibacteria bovis) and Gram negative bacteria (Kebsilla pneumonie; Proteus valgaris and E. coli) in different manner. Also glycyrrhetic acid chloride showed bacteriostatic effect against Bacillus antherasis, Staphylococcus aureus and E.coli. It could be concluded that the synthesis of new derivatives from glycyrrhetic acid gave activity against Gram negative bacteria in different manner. Also the glycyrrhetic acid chloride (original material) may be useful as curative against B. antherasis, E. coli and 5. aureus.