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AuthorEid, Ali H
AuthorEl-Yazbi, Ahmed F
AuthorZouein, Fouad
AuthorArredouani, Abdelilah
AuthorOuhtit, Allal
AuthorRahman, Md M
AuthorZayed, Hatem
AuthorPintus, Gianfranco
AuthorAbou-Saleh, Haissam
Available date2018-09-06T08:46:51Z
Publication Date2018-07-26
Publication NameFrontiers in Physiology
Identifierhttp://dx.doi.org/10.3389/fphys.2018.01018
CitationEid AH, El-Yazbi AF, Zouein F, Arredouani A, Ouhtit A, Rahman MM, Zayed H, Pintus G and Abou-Saleh H (2018) Inositol 1,4,5-Trisphosphate Receptors in Hypertension. Front. Physiol. 9:1018. doi: 10.3389/fphys.2018.01018
URIhttp://hdl.handle.net/10576/11020
AbstractChronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. Evidence supports a role for vascular aging in the development of hypertension involving an impairment in endothelial function together with an alteration in vascular smooth muscle cells (VSMCs) calcium homeostasis leading to increased myogenic tone. Changes in free intracellular calcium levels ([Ca] ) are mediated either by the influx of Ca from the extracellular space or release of Ca from intracellular stores, mainly the sarcoplasmic reticulum (SR). The influx of extracellular Ca occurs primarily through voltage-gated Ca channels (VGCCs), store-operated Ca channels (SOC), and Ca release-activated channels (CRAC), whereas SR-Ca release occurs through inositol trisphosphate receptor (IPR) and ryanodine receptors (RyRs). IPR-mediated SR-Ca release, in the form of Ca waves, not only contributes to VSMC contraction and regulates VGCC function but is also intimately involved in structural remodeling of resistance arteries in hypertension. This involves a phenotypic switch of VSMCs as well as an alteration of cytoplasmic Ca signaling machinery, a phenomena tightly related to the aging process. Several lines of evidence implicate changes in expression/function levels of IPR isoforms in the development of hypertension, VSMC phenotypic switch, and vascular aging. The present review discusses the current knowledge of these mechanisms in an integrative approach and further suggests potential new targets for hypertension management and treatment.
SponsorThis publication was made possible by an MPP fund (#320133) from the American University of Beirut to AE.
Languageen
PublisherFrontiers Media
SubjectCa2+
IP3R
VSMC
aging
hypertension
TitleInositol 1,4,5-Trisphosphate Receptors in Hypertension.
TypeArticle Review
Volume Number9
ESSN1664-042X
dc.accessType Open Access


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