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المؤلفFois, Alessandro Giuseppe
المؤلفPosadino, Anna Maria
المؤلفGiordo, Roberta
المؤلفCossu, Annalisa
المؤلفAgouni, Abdelali
المؤلفRizk, Nasser Moustafa
المؤلفPirina, Pietro
المؤلفCarru, Ciriaco
المؤلفZinellu, Angelo
المؤلفPintus, Gianfranco
تاريخ الإتاحة2018-11-26T08:56:32Z
تاريخ النشر2018-10-21
اسم المنشورOxidative Medicine and Cellular Longevity
المعرّفhttp://dx.doi.org/10.1155/2018/2639081
الاقتباسAlessandro Giuseppe Fois, Anna Maria Posadino, Roberta Giordo, et al., “Antioxidant Activity Mediates Pirfenidone Antifibrotic Effects in Human Pulmonary Vascular Smooth Muscle Cells Exposed to Sera of Idiopathic Pulmonary Fibrosis Patients,” Oxidative Medicine and Cellular Longevity, vol. 2018, Article ID 2639081, 8 pages, 2018. https://doi.org/10.1155/2018/2639081
الرقم المعياري الدولي للكتاب1942-0900
المعرّفArticle ID 2639081
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11182
الملخصIdiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by an exacerbated fibrotic response. Although molecular and cellular determinants involved in the onset and progression of this devastating disease are largely unknown, an aberrant remodeling of the pulmonary vasculature appears to have implications in IPF pathogenesis. Here, we demonstrated for the first time that an increase of reactive oxygen species (ROS) generation induced by sera from IPF patients drives both collagen type I deposition and proliferation of primary human pulmonary artery smooth muscle cells (HPASMCs). IPF sera-induced cellular effects were significantly blunted in cells exposed to the NADPH oxidase inhibitor diphenyleneiodonium (DPI) proving the causative role of ROS and suggesting their potential cellular source. Contrary to IPF naive patients, sera from Pirfenidone-treated IPF patients failed to significantly induce both ROS generation and collagen synthesis in HPASMCs, mechanistically implicating antioxidant properties as the basis for the in vivo effect of this drug.
اللغةen
الناشرHindawi Publishing Corporation
الموضوعOxidative Stress
Idiopathic pulmonary fibrosis
VSMC
Fibrosis
العنوانAntioxidant Activity Mediates Pirfenidone Antifibrotic Effects in Human Pulmonary Vascular Smooth Muscle Cells Exposed to Sera of Idiopathic Pulmonary Fibrosis Patients.
النوعArticle
رقم المجلد2018
ESSN1942-0994
dc.accessType Open Access


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