Aspirin inhibits cancer stem cells properties and growth of glioblastoma multiforme through Rb1 pathway modulation.
Author | Pozzoli, Giacomo |
Author | Marei, Hany E |
Author | Althani, Asma |
Author | Boninsegna, Alma |
Author | Casalbore, Patrizia |
Author | Marlier, Lionel N J L |
Author | Lanzilli, Giulia |
Author | Zonfrillo, Manuela |
Author | Petrucci, Giovanna |
Author | Rocca, Bianca |
Author | Navarra, Pierluigi |
Author | Sgambato, Alessandro |
Author | Cenciarelli, Carlo |
Available date | 2019-02-13T07:24:37Z |
Publication Date | 2019-01-01 |
Publication Name | Journal of Cellular Physiology |
Identifier | http://dx.doi.org/10.1002/jcp.28194 |
Citation | Pozzoli G, Marei HE, Althani A, et al. Aspirin inhibits cancer stem cells properties and growth of glioblastoma multiforme through Rb1 pathway modulation. J Cell Physiol. 2019;1–13. https://doi.org/10.1002/jcp.28194 |
ISSN | 0021-9541 |
Abstract | Several clinical studies indicated that the daily use of aspirin or acetylsalicylic acid reduces the cancer risk via cyclooxygenases (Cox-1 and Cox-2) inhibition. In addition, aspirin-induced Cox-dependent and -independent antitumor effects have also been described. Here we report, for the first time, that aspirin treatment of human glioblastoma cancer (GBM) stem cells, a small population responsible for tumor progression and recurrence, is associated with reduced cell proliferation and motility. Aspirin did not interfere with cell viability but induced cell-cycle arrest. Exogenous prostaglandin E significantly increased cell proliferation but did not abrogate the aspirin-mediated growth inhibition, suggesting a Cox-independent mechanism. These effects appear to be mediated by the increase of p21 and p27 , associated with a reduction of Cyclin D1 and Rb1 protein phosphorylation, and involve the downregulation of key molecules responsible for tumor development, that is, Notch1, Sox2, Stat3, and Survivin. Our results support a possible role of aspirin as adjunctive therapy in the clinical management of GBM patients. |
Language | en |
Publisher | Wiley |
Subject | CSC Cox GBM Rb1 aspirin stemness |
Type | Article |
ESSN | 1097-4652 |
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