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AuthorSouchelnytskyi, S
Available date2019-02-14T08:02:49Z
Publication Date2018-06-01
Publication NameBritish Journal of Cancer - Experimental Oncology
CitationSouchelnytskyi S. Intersection between genes controlling vascularization and angiogenesis in renal cell carcinomas. British Journal of Cancer - Experimental Oncology. Vol 40, Issue (2), P.p. 140-143
ISSN0007-0920
URIhttp://hdl.handle.net/10576/11322
AbstractTo show that application of the systemic analysis may significantly improve comparison of different datasets. Different genes and proteins may converge on the same functional outputs. A comparison of 2 datasets by only identification names of affected molecules may miss that, leading to a conclusion that there is nothing in common for these datasets. Systemic analysis may overcome this limitation, by focusing on functions represented by the identification names. Datasets were retrieved from open sources. Systemic analysis of vascularization features and angiogenesis signature was performed by using Cytoscape and its plugs-in. In contrary to the initial statement of the lack of overlap between the vascularization features and the angiogenesis genes-signature in renal carcinomas, we observed an intersection on the functional level. Analysis of the networks built with identification names of vascularization and angiogenesis datasets showed an intersection, which included potent regulators of vessel formation and growth. Analysis of networks may expose functional links, which may be missed by a direct identification names comparison.
SponsorNPRP9-453-3-089
Languageen
PublisherSpringer Nature
Subjectcancer
angiogenesis
vascularization
systemic analysis
Carcinoma, Renal Cell/genetics
Carcinoma, Renal Cell/pathology
Computational Biology/methods
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Kidney Neoplasms/pathology
Kidney Neoplasms/pathology
Molecular Sequence Annotation
Neovascularization, Pathologic/genetics
Transcriptome
TitleIntersection between genes controlling vascularization and angiogenesis in renal cell carcinomas
TypeArticle
Pagination140-143
Issue Number2
Volume Number40
ESSN1532-1827
dc.accessType Abstract Only


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