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المؤلفGupta, Ishita
المؤلفSareyeldin, Rasha M.
المؤلفAl-Hashimi, Israa
المؤلفAl-Thawadi, Hamda A.
المؤلفAl Farsi, Halema
المؤلفVranic, Semir
المؤلفAl Moustafa, Ala-Eddin
تاريخ الإتاحة2019-03-28T08:07:42Z
تاريخ النشر2019-03-01
اسم المنشورCancers
المعرّفhttp://dx.doi.org/10.3390/cancers11030363
الاقتباسGupta, I.; Sareyeldin, R.M.; Al-Hashimi, I.; Al-Thawadi, H.A.; Al Farsi, H.; Vranic, S.; Al Moustafa, A.-E. Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity. Cancers 2019, 11, 363.
الرقم المعياري الدولي للكتاب2072-6694
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11456
الملخصBreast cancer is the most frequent cause of cancer-related deaths among women worldwide. It is classified into four major molecular subtypes. Triple-negative breast cancers (TNBCs), a subgroup of breast cancer, are defined by the absence of estrogen and progesterone receptors and the lack of HER-2 expression; this subgroup accounts for ~15% of all breast cancers and exhibits the most aggressive metastatic behavior. Currently, very limited targeted therapies exist for the treatment of patients with TNBCs. On the other hand, it is important to highlight that knowledge of the molecular biology of breast cancer has recently changed the decision-making process regarding the course of cancer therapies. Thus, a number of new techniques, such as gene profiling and sequencing, proteomics, and microRNA analysis have been used to explore human breast carcinogenesis and metastasis including TNBC, which consequently could lead to new therapies. Nevertheless, based on evidence thus far, genomics profiles (gene and miRNA) can differ from one geographic location to another as well as in different ethnic groups. This review provides a comprehensive and updated information on the genomics profile alterations associated with TNBC pathogenesis associated with different ethnic backgrounds.
راعي المشروعQatar University: QUCG-CMED-2018\2019-3, QUSD-CMED-2018-2 and QUST-1-CMED-2019-18.
اللغةen
الناشرMDPI
الموضوعbreast cancer
gene expression prpfiling
miRNA
triple negative breast cancer
biomarkers
microarray
العنوانTriple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity.
النوعArticle
رقم المجلد11
رقم المجلد3
ESSN2072-6694
dc.accessType Open Access


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