Show simple item record

AuthorDjouhri, Laiche
AuthorMalki, MohammedImad
AuthorZeidan, Asad
AuthorNagi, Karim
AuthorSmith, Trevor
Available date2019-04-30T07:00:49Z
Publication Date2019-04-01
Publication NameJournal of Drug Targeting
Identifierhttp://dx.doi.org/10.1080/1061186X.2019.1608552
CitationLaiche Djouhri, MohammedImad Malki, Asad Zeidan, Karim Nagi & Trevor Smith (2019): Activation of Kv7 channels with the anticonvulsant retigabine alleviates neuropathic pain behaviour in the streptozotocin rat model of diabetic neuropathy, Journal of Drug Targeting, DOI: 10.1080/1061186X.2019.1608552
ISSN1061-186X
URIhttp://hdl.handle.net/10576/11512
AbstractDiabetic peripheral neuropathy (DPN) is the most incapacitating complication of diabetes mellitus. Up to 50% of patients with DPN develop peripheral neuropathic pain (PNP). The underlying ionic and molecular mechanisms of diabetic PNP (DPNP) are poorly understood. However, voltage gated potassium (K7) channels which have been implicated in the pathogenesis of other types of PNP are likely to be involved. Here we examined, in the streptozotocin (STZ) rat model of DPNP, whether activating the Kv7 channels with a potent activator retigabine (ezogabine) would reverse/attenuate behavioural signs of DPNP. STZ rats exhibited behavioural indices of mechanical and heat hypersensitivity, but not cold hypersensitivity or spontaneous pain, 35 days after STZ injection. Retigabine given at a dose of 15 mg/kg (but not at 7.5 mg/kg, i.p.) significantly attenuated mechanical, but not heat hypersensitivity in DPNP rats, and was as effective as the positive control gabapentin. This analgesic effect of retigabine was completely reversed by the K7/M channel blocker XE991 (3 mg/kg, i.p.) indicating that the anti-allodynic effects of retigabine were mediated by K7 channels. In conclusion, the findings suggest that Kv7 channels are involved in DPNP pathogenesis, and that strategies that target their activation may prove to be effective in treating DPNP.
Languageen
PublisherTaylor & Francis (Routledge)
Subjectbehavior
chronic pain
diabetic neuropathy
neuropathic pain
pain hypersensitivity
TitleActivation of K7 channels with the anticonvulsant retigabine alleviates neuropathic pain behaviour in the streptozotocin rat model of diabetic neuropathy.
TypeArticle
Pagination1-25
ESSN1029-2330
dc.accessType Abstract Only


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record