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المؤلفMaaliki, Dina
المؤلفShaito, Abdullah A
المؤلفPintus, Gianfranco
المؤلفEl-Yazbi, Ahmed
المؤلفEid, Ali H
تاريخ الإتاحة2019-05-30T08:59:54Z
تاريخ النشر2019-05-01
اسم المنشورCurrent Opinion in Pharmacology
المعرّفhttp://dx.doi.org/10.1016/j.coph.2019.04.014
الاقتباسMaaliki D, Shaito AA, Pintus G, El-Yazbi A, Eid AH. Flavonoids in hypertension: a brief review of the underlying mechanisms. Curr Opin Pharmacol. 2019 May 15;45:57-65. doi: 10.1016/j.coph.2019.04.014.
الرقم المعياري الدولي للكتاب1471-4892
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11621
الملخصFlavonoids are a diverse group of bioactive polyphenolic compounds abundant in dietary plants and herbs. Regular consumption of flavonoids exerts cardio-vasculoprotective effects and may reduce the onset or progression of many cardiovascular diseases, particularly hypertension. Observational studies suggest inverse associations among either of these three combinations: a) anthocyanin intake and risk of myocardial infarction (MI), b) flavanone intake and risk of ischemic stroke and c) flavonol intake and risk of type 2 diabetes mellitus. Human randomized controlled trials (RCTs) show that catechins and quercetin impart significant blood pressure lowering effects. Mechanistically, flavonoids mediate their antihypertensive effects through increasing nitric oxide (NO) bioavailability, reducing endothelial cell oxidative stress or modulating vascular ion channel activity. In this review, we focus on the six main subgroups of flavonoids, namely flavones, flavonols, flavanols, flavanones, anthocyanins, and isoflavones. We further discuss their antihypertensive effects, and their possible mechanisms of regulating blood pressure. We conclude by addressing the safety of these compounds as well as their potential use in hypertension management and treatment.
راعي المشروعThis publication was made possible by an MPP fund (#320133) from the American University of Beirut to Ali Ei.
اللغةen
الناشرElsevier
الموضوعFlavonoids and hypertension
العنوانFlavonoids in hypertension: a brief review of the underlying mechanisms.
النوعArticle
الصفحات57-65
رقم المجلد45
ESSN1471-4973
dc.accessType Abstract Only


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