Spray-Dried Alginate Microparticles for Potential Intranasal Delivery of Ropinirole Hydrochloride: Development, Characterization and Histopathological Evaluation
المؤلف | Hussein, Nozad |
المؤلف | Omer, Huner |
المؤلف | Ismael, Ava |
المؤلف | Alhnan, Mohamed |
المؤلف | Elhissi, Abdelbary |
المؤلف | Ahmed, Waqar |
تاريخ الإتاحة | 2019-07-23T08:49:18Z |
تاريخ النشر | 2019-01-01 |
اسم المنشور | Pharmaceutical Development and Technology |
المعرّف | http://dx.doi.org/10.1080/10837450.2019.1567762 |
الاقتباس | Nozad Hussein, Huner Omer, Ava Ismael, Mohamed Albed Alhnan, Abdelbary Elhissi & Waqar Ahmed (2019): Spray-Dried Alginate Microparticles for Potential Intranasal Delivery of Ropinirole Hydrochloride: Development, Characterization and Histopathological Evaluation, Pharmaceutical Development and Technology, DOI: 10.1080/10837450.2019.1567762 |
الرقم المعياري الدولي للكتاب | 1083-7450 |
الملخص | Ropinirole hydrochloride (RH) is an anti-Parkinson drug with relativity low oral bioavailability owing to its extensive hepatic first pass metabolism. Spray-dried mucoadhesive alginate microspheres of RH were developed and characterized followed by histopathological evaluation using nasal tissue isolated from sheep. Spherical microparticles having high product yield (around 70%) were obtained when the inlet temperature of spray drying was 140 °C. Fourier Transform Infrared (FTIR) studies revealed the compatibility of the drug with the polymer, and scanning electron microscopy (SEM) showed that drug-loaded microparticles were spherical, and the apparent surface roughness was inversely related to the ratio of polymer to drug. Furthermore, size of the spray-dried particles were in the range of 2.5 - 4.37 µm, depending on formulation. All formulations had high drug encapsulation efficiencies (101 - 106%). Drug loaded into the polymeric particles was in the amorphous state and drug molecules were molecularly dispersed in the polymeric matrix of the microparticles which were revealed by X-ray diffraction and differential scanning calorimetry (DSC), respectively. The in vitro drug release was influenced by polymer concentration. Histopathological study demonstrated that RH-loaded sodium alginate microparticles was safe to nasal epithelium. In conclusion, spray drying of RH using sodium alginate polymer has produced microparticles of suitable characteristics for potential intranasal administration. |
راعي المشروع | Iraqi government and Qatar University |
اللغة | en |
الناشر | Taylor & Francis |
الموضوع | Pharmaceutics nose brain delivery microparticles |
النوع | Article |
ESSN | 1097-9867 |
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