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المؤلفAndrews, Sarah F
المؤلفChambers, Michael J
المؤلفSchramm, Chaim A
المؤلفPlyler, Jason
المؤلفRaab, Julie E
المؤلفKanekiyo, Masaru
المؤلفGillespie, Rebecca A
المؤلفRansier, Amy
المؤلفDarko, Sam
المؤلفHu, Jianfei
المؤلفChen, Xuejun
المؤلفYassine, Hadi M
المؤلفBoyington, Jeffrey C
المؤلفCrank, Michelle C
المؤلفChen, Grace L
المؤلفCoates, Emily
المؤلفMascola, John R
المؤلفDouek, Daniel C
المؤلفGraham, Barney S
المؤلفLedgerwood, Julie E
المؤلفMcDermott, Adrian B
تاريخ الإتاحة2019-08-21T05:21:26Z
تاريخ النشر2019-07-01
اسم المنشورImmunity
المعرّفhttp://dx.doi.org/10.1016/j.immuni.2019.06.024
الاقتباسAndrews SF, Chambers MJ, Schramm CA, Plyler J, Raab JE, Kanekiyo M, Gillespie RA, Ransier A, Darko S, Hu J, Chen X, Yassine HM, Boyington JC, Crank MC, Chen GL, Coates E, Mascola JR, Douek DC, Graham BS, Ledgerwood JE, McDermott AB. Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin. Immunity. 2019 Jul 16. pii: S1074-7613(19)30294-8. doi: 10.1016/j.immuni.2019.06.024.
الرقم المعياري الدولي للكتاب1074-7613
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11698
الملخصVaccine-induced memory B cell responses to evolving viruses like influenza A involve activation of pre-existing immunity and generation of new responses. To define the contribution of these two types of responses, we analyzed the response to H7N9 vaccination in H7N9-naive adults. We performed comprehensive comparisons at the single-cell level of the kinetics, Ig repertoire, and activation phenotype of established pre-existing memory B cells recognizing conserved epitopes and the newly generated memory B cells directed toward H7 strain-specific epitopes. The recall response to conserved epitopes on H7 HA involved a transient expansion of memory B cells with little observed adaptation. However, the B cell response to newly encountered epitopes was phenotypically distinct and generated a sustained memory population that evolved and affinity matured months after vaccination. These findings establish clear differences between newly generated and pre-existing memory B cells, highlighting the challenges in achieving long-lasting, broad protection against an ever-evolving virus.
اللغةen
الناشرElsevier
الموضوعH7N9
Ig repertoire
Tbet
activated B cells
hemagglutinin
influenza
memory B cells
vaccine response
العنوانActivation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin.
النوعArticle
الصفحات398-410
رقم العدد2
رقم المجلد51
ESSN1097-4180
dc.accessType Abstract Only


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