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AuthorKhalil R.
AuthorKarim A.A.
AuthorKhedr E.
AuthorMoftah M.
AuthorMoustafa A.A.
Available date2019-09-24T08:16:00Z
Publication Date2018
Publication NameFrontiers in Cellular Neuroscience
ResourceScopus
ISSN16625102
URIhttp://dx.doi.org/10.3389/fncel.2018.00468
URIhttp://hdl.handle.net/10576/11924
AbstractSeveral factors regulate cortical development, such as changes in local connectivity and the influences of dynamical synapses. In this study, we simulated various factors affecting the regulation of neural network activity during cortical development. Previous studies have shown that during early cortical development, the reversal potential of GABA A shifts from depolarizing to hyperpolarizing. Here we provide the first integrative computational model to simulate the combined effects of these factors in a unified framework (building on our prior work: Khalil et al., 2017a,b). In the current study, we extend our model to monitor firing activity in response to the excitatory action of GABA A . Precisely, we created a Spiking Neural Network model that included certain biophysical parameters for lateral connectivity (distance between adjacent neurons) and nearby local connectivity (complex connections involving those between neuronal groups). We simulated different network scenarios (for immature and mature conditions) based on these biophysical parameters. Then, we implemented two forms of Short-term synaptic plasticity (depression and facilitation). Each form has two distinct kinds according to its synaptic time constant value. Finally, in both sets of networks, we compared firing rate activity responses before and after simulating dynamical synapses. Based on simulation results, we found that the modulation effect of dynamical synapses for evaluating and shaping the firing activity of the neural network is strongly dependent on the physiological state of GABA A . Moreover, the STP mechanism acts differently in every network scenario, mirroring the crucial modulating roles of these critical parameters during cortical development. Clinical implications for pathological alterations of GABAergic signaling in neurological and psychiatric disorders are discussed. ? 2018 Khalil, Karim, Khedr, Moftah and Moustafa.
SponsorKA 4267/3-1 Deutsche Forschungsgemeinschaft
Languageen
PublisherFrontiers Media S.A.
SubjectCortical development
Dynamical synapses
Firing rate activity
GABAA signaling
In vitro
Local connectivity
STD
STF
TitleDynamic communications between GABA A switch, local connectivity, and synapses during cortical development: A computational study
TypeArticle
Volume Number12
dc.accessType Abstract Only


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