Rheological and controlled release properties of hydrogels based on mushroom hyperbranched polysaccharide and xanthan gum
المؤلف | ZhangR. |
المؤلف | TaoY. |
المؤلف | XuW. |
المؤلف | XiaoS. |
المؤلف | DuS. |
المؤلف | ZhouY. |
المؤلف | HasanA. |
تاريخ الإتاحة | 2019-10-03T10:50:04Z |
تاريخ النشر | 2018 |
اسم المنشور | International Journal of Biological Macromolecules |
المصدر | Scopus |
الرقم المعياري الدولي للكتاب | 1418130 |
الملخص | A hyperbranched polysaccharide, coded as TM3a, was extracted from the Pleurotus tuber-regium sclerotia. TM3a was hybridized with xanthan gum (XG) by chemical crosslinking using sodium trimetaphosphate (STMP) to obtain new hydrogels with self-healing and release-controlled properties. The oscillatory rheological measurements indicated that chemically crosslinking was happened immediately on mixing STMP solutions into the XG-TM3a solutions, and the crosslinked network developed slightly as time increased. The resultant hydroges were disturbed into the loose structures and regrouped the microstructure in 2 min when a large and a small amplitude oscillation were applied in turn, suggesting a self-healable property. The XG-TM3a-STMP hydrogels exhibited shear-thinning behavior with yield stress. The storage modulus of the XG5-TM3a-STMP hydrogel was 445.2 Pa at 1% strain and 243.3 Pa at 100% strain, and yield stress was 160.6 Pa, which was higher than the corresponding value of the XG5-STMP hydrogel. The morphological observation indicated the aggregates of double helical XG chains exhibited directional arrangement, and were combined with the TM3a aggregates to constitute a network of hierarchical structures. The hybrid hydrogels with enhanced mechanical properties displayed good drug loading efficiencies and sustained drug release properties. |
راعي المشروع | This article was made possible by the grant#21344006 by National Natural Science Foundation of China ,grant#D20161603by the Foundation of Hubei Educational Committee of China,grant#GCC-2017-005by Qatar University,and grant#NPRP9-144-3-021funded by Qatar national Research Fund(apart of Qatar Foundation). |
اللغة | en |
الناشر | Elsevier B.V. |
الموضوع | Controlledrelease Hydrogel Hyperbranchedpolysaccharide Rheologicalproperty Xanthangum |
النوع | Article |
الصفحات | 2399-2409 |
رقم المجلد | 120 |
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