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المؤلفAugustine, Robin
المؤلفHasan, Anwarul
المؤلفPatan, Noorunnisa Khanam
المؤلفAugustine, Anitha
المؤلفDalvi, Yogesh B
المؤلفVarghese, Ruby
المؤلفUnni, Raghunath Narayanan
المؤلفKalarikkal, Nandakumar
المؤلفAl Moustafa, Ala-Eddin
المؤلفThomas, Sabu
تاريخ الإتاحة2019-10-16T05:48:44Z
تاريخ النشر2019-07-01
اسم المنشورMacromolecular Bioscience
المعرّفhttp://dx.doi.org/10.1002/mabi.201900058
الاقتباسAugustine, R., Hasan, A., Patan, N. K., Augustine, A., Y. B Dalvi, , Varghese, R., Unni, R. N., Kalarikkal, N., Al Moustafa, A.‐E., Thomas, S., Titanium Nanorods Loaded PCL Meshes with Enhanced Blood Vessel Formation and Cell Migration for Wound Dressing Applications. Macromol. Biosci. 2019, 19, 1900058. https://doi.org/10.1002/mabi.201900058
الرقم المعياري الدولي للكتاب1616-5187
معرّف المصادر الموحدhttp://hdl.handle.net/10576/12123
الملخصProper management of nonhealing wounds is an imperative clinical challenge. For the effective healing of chronic wounds, suitable wound coverage materials with the capability to accelerate cell migration, cell proliferation, angiogenesis, and wound healing are required to protect the healing wound bed. Biodegradable polymeric meshes are utilized as effective wound coverage materials to protect the wounds from the external environment and prevent infections. Among them, electrospun biopolymeric meshes have got much attention due to their extracellular matrix mimicking morphology, ability to support cell adhesion, and cell proliferation. Herein, electrospun nanocomposite meshes based on polycaprolactone (PCL) and titanium dioxide nanorods (TNR) are developed. TNR incorporated PCL meshes are fabricated by electrospinning technique and characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy (FTIR) analysis, and X-Ray diffraction (XRD) analysis. In vitro cell culture studies, in ovo angiogenesis assay, in vivo implantation study, and in vivo wound healing study are performed. Interestingly, obtained in vitro and in vivo results demonstrated that the presence of TNR in the PCL meshes greatly improved the cell migration, proliferation, angiogenesis, and wound healing. Owing to the above superior properties, they can be used as excellent biomaterials in wound healing and tissue regeneration applications.
راعي المشروعThis article was made possible by the NPRP9‐144‐3‐021 grant funded by Qatar National Research Fund (a part of Qatar Foundation). The statements made here are totally responsibility of authors.
اللغةen
الناشرWiley
الموضوعTiO2 nanorods
angiogenesis
electrospinning
polycaprolactone
wound dressings
العنوانTitanium Nanorods Loaded PCL Meshes with Enhanced Blood Vessel Formation and Cell Migration for Wound Dressing Applications.
النوعArticle
رقم العدد7
رقم المجلد19
ESSN1616-5195
dc.accessType Abstract Only


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