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المؤلفAl-Sulaiti, Haya
المؤلفDiboun, Ilhame
المؤلفAgha, Maha V
المؤلفMohamed, Fatima F S
المؤلفAtkin, Stephen
المؤلفDömling, Alex S
المؤلفElrayess, Mohamed A
المؤلفMazloum, Nayef A
تاريخ الإتاحة2019-11-19T09:24:31Z
تاريخ النشر2019-10-22
اسم المنشورJournal of Translational Medicine
المعرّفhttp://dx.doi.org/10.1186/s12967-019-2096-8
الاقتباسAl-Sulaiti, H., Diboun, I., Agha, M.V. et al. Metabolic signature of obesity-associated insulin resistance and type 2 diabetes. J Transl Med 17, 348 (2019) doi:10.1186/s12967-019-2096-8
المعرّفArticle number: 348
معرّف المصادر الموحدhttp://hdl.handle.net/10576/12319
الملخصObesity is associated with an increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity and exhibit a lower risk of associated comorbidities. The underlying metabolic pathways differentiating obese insulin sensitive (OIS) and obese insulin resistant (OIR) individuals remain unclear. In this study, 107 subjects underwent untargeted metabolomics of serum samples using the Metabolon platform. Thirty-two subjects were lean controls whilst 75 subjects were obese including 20 OIS, 41 OIR, and 14 T2DM individuals. Our results showed that phospholipid metabolites including choline, glycerophosphoethanolamine and glycerophosphorylcholine were significantly altered from OIS when compared with OIR and T2DM individuals. Furthermore, our data confirmed changes in metabolic markers of liver disease, vascular disease and T2DM, such as 3-hydroxymyristate, dimethylarginine and 1,5-anhydroglucitol, respectively. This pilot data has identified phospholipid metabolites as potential novel biomarkers of obesity-associated insulin sensitivity and confirmed the association of known metabolites with increased risk of obesity-associated insulin resistance, with possible diagnostic and therapeutic applications. Further studies are warranted to confirm these associations in prospective cohorts and to investigate their functionality.
اللغةen
الناشرBMC
الموضوعBlood metabolites
Insulin resistance
Insulin sensitivity
Metabolomics
Type 2 diabetes mellitus
العنوانMetabolic signature of obesity-associated insulin resistance and type 2 diabetes.
النوعArticle
رقم المجلد17
ESSN1479-5876
dc.accessType Open Access


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