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المؤلفBhatti S.A.
المؤلفKhan M.Z.
المؤلفHassan Z.U.
المؤلفSaleemi M.K.
المؤلفKhatoon A.
المؤلفAbidin Z.U.
المؤلفHameed M.R.
تاريخ الإتاحة2020-03-03T06:19:03Z
تاريخ النشر2018
اسم المنشورToxicon
المصدرScopus
الرقم المعياري الدولي للكتاب410101
معرّف المصادر الموحدhttp://dx.doi.org/10.1016/j.toxicon.2018.08.012
معرّف المصادر الموحدhttp://hdl.handle.net/10576/13108
الملخصThis study aimed to evaluate the effect of dietary ochratoxin A (OA), in the presence and absence of L-carnitine (LC) and vitamin E (VE), on the humoral immune responses of White Leghorn cockerels (WLC). One-day old white male Leghorn chicks were divided into 12 groups, having 20 birds each and were offered ration contaminated with OA (1.0 or 2.0 mg/kg feed) alone and concurrently with LC (1.0 g/kg) and/or VE (0.2 g/kg), for 42 days. The humoral immune responses were accessed by lymphoproliferative response to avian tuberculin, in-vivo phagosomes activity to carbon particles and antibody response to the sheep red blood cells (SRBCs). The dietary addition of OA alone suppressed the humoral immune responses, however, the exposure of birds to 1.0 mg/kg OA in the presence of LC and/or VE showed a significant reduction in OA induced immunotoxicity. This protective response was absent in the birds fed 2.0 mg/kg OA in the presence and absence of LC and/or VE. Histopathological and morphometric examination of the bursa of Fabricius exhibited a decrease in the severity and frequency of OA induced lesions in the presence of dietary LC and/or VE. The use of LC and VE as dietary supplement, can effectively overcome OA (≤1.0 mg/kg) induced immunosuppression.
راعي المشروعThis work has been extracted from the M. Phil thesis research in toxicopathology laboratory of Department of Pathology Faculty of Veterinary Science University of Agriculture Faisalabad Pakistan. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
اللغةen
الناشرElsevier Ltd
الموضوعDietary supplement
Immunotoxicity
L-carnitine
Ochratoxin A
Vitamin E
العنوانDietary L-carnitine and vitamin-E; a strategy to combat ochratoxin-A induced immunosuppression
النوعArticle
الصفحات62 - 71
رقم المجلد153
dc.accessType Abstract Only


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