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AuthorThuan,Duong Thi Bich
AuthorZayed,Hatem
AuthorEid,Ali H.
AuthorAbou-Saleh,Haissam
AuthorNasrallah,Gheyath K.
AuthorMangoni,Arduino A.
AuthorPintus,Gianfranco
Available date2020-03-03T06:19:05Z
Publication Date2018
Publication NameFrontiers in Immunology
ResourceScopus
ISSN16643224
URIhttp://dx.doi.org/10.3389/fimmu.2018.01985
URIhttp://hdl.handle.net/10576/13131
AbstractSystemic sclerosis (SSc), an autoimmune disease that is associated with a number of genetic and environmental risk factors, is characterized by progressive fibrosis and microvasculature damage in the skin, lungs, heart, digestive system, kidneys, muscles, joints, and nervous system. These abnormalities are associated with altered secretion of growth factor and profibrotic cytokines, such as transforming growth factor-beta (TGF-β), interleukin-4 (IL-4), platelet-derived growth factor (PDGF), and connective-tissue growth factor (CTGF). Among the cellular responses to this proinflammatory environment, the endothelial cells phenotypic conversion into activated myofibroblasts, a process known as endothelial to mesenchymal transition (EndMT), has been postulated. Reactive oxygen species (ROS) might play a key role in SSs-associated fibrosis and vascular damage by mediating and/or activating TGF-β-induced EndMT, a phenomenon that has been observed in other disease models. In this review, we identified and critically appraised published studies investigating associations ROS and EndMT and the presence of EndMT in SSc, highlighting a potential link between oxidative stress and EndMT in this condition.
SponsorThis review article constitutes original research work that was part of Dr. Thuan's Doctoral Thesis (185). This research was supported by grants from the Qatar National Research Fund (UREP20-051-3-012) and the Qatar University (QUCG-CHS-2018/2019-1). The article processing charge (APC) for the publication of this article was funded by the (Qatar National Library).
Languageen
PublisherFrontiers Media S.A.
SubjectEndothelial-to-Mesenchymal Transition
Oxidative stress
Reactive oxygen species
Scleroderma
Systemic sclerosis
TitleA potential link between oxidative stress and endothelial-to-mesenchymal transition in systemic sclerosis
TypeArticle Review
Issue NumberSEP
Volume Number9
dc.accessType Abstract Only


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