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AuthorCesar A., Moran
AuthorLindholm, Kaleigh E.
AuthorBrunnström, Hans
AuthorLangman, Gerald
AuthorJang, Se Jin
AuthorSpagnolo, Dominic
AuthorChai, Siaw Ming
AuthorLaycock, Andrew
AuthorFalconieri, Giovanni
AuthorPizzolitto, Stefano
Authorde Pellegrin, Alessandro
AuthorMedeiros, Filomena
AuthorEdmunds, Lilian
AuthorCatarino, Ana
AuthorCunha, Fernando
AuthorRo, Jae
AuthorPina-Oviedo, Sergio
AuthorTorrealba, Jose
AuthorCoppola, Domenico
AuthorPetersson, Fredrik
AuthorOon, Ming Lian
AuthorElmberger, Goran
AuthorCajal, Santiago Ramon y
AuthorValero, Irene Sansano
AuthorDalurzo, Liliana
AuthorSoares, Fernando
AuthorCampos, Antonio H.
AuthorVranic, Semir
AuthorSkenderi, Faruk
AuthorCorrea, Arlene M.
AuthorSepesi, Boris
AuthorRice, David
AuthorMehran, Reza
AuthorWalsh, Garrett
Available date2020-03-08T04:47:26Z
Publication Date2020-03-05
Publication NameHuman Pathology
Identifierhttp://dx.doi.org/10.1016/j.humpath.2020.02.005
CitationMoran CA, Lindholm KE, Brunnström H, Langman G, Jang SJ, Spagnolo D, Chai SM, Laycock A, Falconieri G, Pizzolitto S, de Pellegrin A, Medeiros F, Edmunds L, Catarino A, Cunha F, Ro J, Pina-Oviedo S, Torrealba J, Coppola D, Petersson F, Oon ML, Elmberger G, Cajal SRy, Valero IS, Dalurzo L, Soares F, Campos AH, Vranic S, Skenderi F, Correa AM, Sepesi B, Rice D, Mehran R, Walsh G, Typical and atypical carcinoid tumors of the lung: A Clinicopathological correlation OF OF 783 cases with Emphasis on histological features, Human Pathology, https://doi.org/10.1016/ j.humpath.2020.02.005.
ISSN0046-8177
URIhttps://www.sciencedirect.com/science/article/pii/S0046817720300460?v=s5
URIhttp://hdl.handle.net/10576/13272
AbstractABSTRACT We present 783 surgical resections of typical and atypical carcinoid tumors of the lung identified in the pathology files of 20 different pathology departments. All cases were critically reviewed for clinical and pathological features and further correlated with clinical outcome. Long-term follow-up was obtained in all the patients and statistically analyzed to determine significance of the different parameters evaluated. Of the histopathological features analyzed, the presence of mitotic activity of 4 mitoses or more per 2mm2, necrosis, lymphatic invasion and lymph node metastasis were identified as statistically significant. Tumors measuring 3 cm or more were also identified as statistically significant and correlate with clinical outcome. Based on our analysis, we consider that the separation of low and intermediate grade neuroendocrine neoplasms of the lung needs to be readjusted in terms of mitotic count as the risk of over grading these neoplasms exceeds 10% under the current criteria. We also consider that tumor size is an important feature to be considered in the assessment of these neoplasms and together with the histological grade of the tumor offers important features that can be correlated with clinical outcome.
Languageen
PublisherElsevier
Subjectlung cancer
carcinoid
atypical carcinoid
pathology
TitleTypical and atypical carcinoid tumors of the lung: A Clinicopathological correlation of 783 cases with Emphasis on histological features
TypeArticle
dc.accessType Abstract Only


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