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المؤلفMcLure A.
المؤلفFuruya-Kanamori L.
المؤلفClements A.C.A.
المؤلفKirk M.
المؤلفGlass K.
تاريخ الإتاحة2020-03-18T10:47:14Z
تاريخ النشر2019
اسم المنشورJournal of Hospital Infection
المصدرScopus
الرقم المعياري الدولي للكتاب1956701
معرّف المصادر الموحدhttp://dx.doi.org/10.1016/j.jhin.2019.03.001
معرّف المصادر الموحدhttp://hdl.handle.net/10576/13399
الملخصBackground: Clostridium difficile infection (CDI)is the leading cause of antibiotic-associated diarrhoea with peak incidence in late winter or early autumn. Although CDI is commonly associated with hospitals, community transmission is important. Aim: To explore potential drivers of CDI seasonality and the effect of community-based interventions to reduce transmission. Methods: A mechanistic compartmental model of C. difficile transmission in a hospital and surrounding community was used to determine the effect of reducing transmission or antibiotic prescriptions in these settings. The model was extended to allow for seasonal antibiotic prescriptions and seasonal transmission. Findings: Modelling antibiotic seasonality reproduced the seasonality of CDI, including approximate magnitude (13.9 15.1% above annual mean)and timing of peaks (0.71.0 months after peak antibiotics). Halving seasonal excess prescriptions reduced the incidence of CDI by 618%. Seasonal transmission produced larger seasonal peaks in the prevalence of community colonization (14.8 22.1% above mean)than seasonal antibiotic prescriptions (0.2 1.7% above mean). Reducing transmission from symptomatic or hospitalized patients had little effect on community-acquired CDI, but reducing transmission in the community by 7% or transmission from infants by 30% eliminated the pathogen. Reducing antibiotic prescription rates led to approximately proportional reductions in infections, but limited reductions in the prevalence of colonization. Conclusion: Seasonal variation in antibiotic prescription rates can account for the observed magnitude and timing of C. difficile seasonality. Even complete prevention of transmission from hospitalized patients or symptomatic patients cannot eliminate the pathogen, but interventions to reduce transmission from community residents or infants could have a large impact on both hospital- and community-acquired infections.
راعي المشروعThis work was supported by National Health and Medical Research Council to A.C.A.C. (# 1058878 ) and M.K. ( GNT1145997 ), and an Australian Government Research Training Program Scholarship to A.M. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Appendix A
اللغةen
الناشرW.B. Saunders Ltd
الموضوعClostridium difficile
Community-acquired infections
Hospital-acquired infections
Mathematical model
Seasonal infections
العنوانSeasonality and community interventions in a mathematical model of Clostridium difficile transmission
النوعArticle
الصفحات157-164
رقم العدد2
رقم المجلد102
dc.accessType Abstract Only


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