Co-presence of Epstein-Barr virus and high-risk human papillomaviruses in Syrian colorectal cancer samples.
Author | Malki, Mohammed I |
Author | Gupta, Ishita |
Author | Fernandes, Queenie |
Author | Aboulkassim, Tahar |
Author | Yasmeen, Amber |
Author | Vranic, Semir |
Author | Al Moustafa, Ala-Eddin |
Author | Al-Thawadi, Hamda A |
Available date | 2020-03-22T09:48:21Z |
Publication Date | 2020-03-18 |
Publication Name | Human Vaccines and Immunotherapeutics |
Identifier | http://dx.doi.org/10.1080/21645515.2020.1726680 |
Citation | Mohammed I. Malki, Ishita Gupta, Queenie Fernandes, Tahar Aboulkassim, Amber Yasmeen, Semir Vranic, Ala-Eddin Al Moustafa & Hamda A. Al-Thawadi (2020) Co-presence of Epstein–Barr virus and high-risk human papillomaviruses in Syrian colorectal cancer samples, Human Vaccines & Immunotherapeutics, DOI: 10.1080/21645515.2020.1726680 |
ISSN | 2164-5515 |
Abstract | We recently performed two studies exploring the presence of Epstein-Barr virus (EBV) and high-risk human papillomaviruses (HPVs) types 16, 18, 31, 33 and 35 in human colorectal cancers from the Syrian population. Herein, we report that EBV and high-risk HPVs are co-present in colorectal cancers from Syria. We reveal that 17 (~17%) of 102 cancer samples are positive for both EBV and high-risk HPVs and their co-presence is associated with high/intermediate grade invasive carcinomas. These data suggest that EBV and high-risk HPVs are co-present in human colorectal cancers where they might cooperate on the initiation and/or progression of these cancers. Thus, we believe that future studies are necessary to confirm the co-presence of these oncoviruses and their cooperative role in human colorectal carcinogenesis. |
Sponsor | This work was supported by grants from Qatar University: QUHI-CMED-19/20-1 and GCC # 2017-002 QU/KU. |
Language | en |
Publisher | Taylor & Francis |
Subject | EBV Syrian population cancer phenotype colorectal cancer high-risk HPV |
Type | Article |
ESSN | 2164-554X |
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