CTLA4-Ig (abatacept): a promising investigational drug for use in type 1 diabetes.
المؤلف | Rachid, Ousama |
المؤلف | Osman, Aisha |
المؤلف | Abdi, Reza |
المؤلف | Haik, Yousef |
تاريخ الإتاحة | 2020-03-23T06:17:42Z |
تاريخ النشر | 2020-03-12 |
اسم المنشور | Expert Opinion on Investigational Drugs |
المعرّف | http://dx.doi.org/10.1080/13543784.2020.1727885 |
الرقم المعياري الدولي للكتاب | 1354-3784 |
الملخص | Type 1 diabetes (T1D) is an autoimmune disease that results from the destruction of insulin-producing beta cells in the pancreas; it leads to the under or nonproduction of insulin. T1D is associated with numerous life-threatening micro- and macro-vascular complications and early deaths, hence the development of preventative strategies is a priority for research. The authors outline the drawbacks of available treatments for T1D and assess the three key strategies for prevention, including immunomodulatory therapies which hold the most potential. This article examines CTLA4-Ig and its efficacy and safety profiles. Finally, the pharmacokinetic parameters and pharmacodynamic markers of abatacept are shown and in clinical trials, guiding dosage regimen recommendations for future investigational studies. Immunomodulation is one of the promising strategies for decelerating the progression of beta-cell destruction after the onset of T1D. It holds the advantage of specific immune modulation without systemic general immunosuppression. Preclinical and clinical studies have yielded promising data on the use of CTLA4-Ig in T1D. Variations in response to CTLA4-Ig might be partially explained by the existence of multiple T1D subtypes with varying baseline innate inflammatory/regulatory bias and the rate of C-peptide decline. |
راعي المشروع | This work was made possible by the National Priorities Research Program award [NPRP9-350-3-074] from the Qatar National Research Fund (a member of The Qatar Foundation). The contents herein are solely the responsibility of the author. |
اللغة | en |
الناشر | Taylor & Francis |
الموضوع | Abatacept CTLA4-Ig T-cell co-stimulation autoimmune disease beta cells diabetes immunomodulation type 1 diabetes |
النوع | Article Review |
الصفحات | 221-236 |
رقم العدد | 3 |
رقم المجلد | 29 |
ESSN | 1744-7658 |
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