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AuthorSareyeldin, Rasha M.
AuthorGupta, Ishita
AuthorAl-Hashimi, Israa
AuthorAl-Thawadi, Hamda A.
AuthorAl Farsi, Halema F.
AuthorVranic, Semir
AuthorAl Moustafa, Ala-Eddin
Available date2020-03-25T12:18:05Z
Publication Date2019
Publication NameCancers
ResourceScopus
ISSN20726694
URIhttp://dx.doi.org/10.3390/cancers11050646
URIhttp://hdl.handle.net/10576/13505
AbstractBreast cancer is the second most common cause of cancer-related deaths among women worldwide. It is a heterogeneous disease with four major molecular subtypes. One of the subtypes, human epidermal growth factor receptor 2 (HER2)-enriched (HER2-positive) is characterized by the absence of estrogen and progesterone receptors and overexpression of HER2 receptor, and accounts for 15-20% of all breast cancers. Despite the anti-HER2 and cytotoxic chemotherapy, HER2 subtype is an aggressive disease with significant mortality. Recent advances in molecular biology techniques, including gene expression profiling, proteomics, and microRNA analysis, have been extensively used to explore the underlying mechanisms behind human breast carcinogenesis and metastasis including HER2-positive breast cancer, paving the way for developing new targeted therapies. This review focuses on recent advances on gene expression and miRNA status in HER2-positive breast cancer.
SponsorWe are thankful to Amal Kassab for her critical reading of the manuscript. The publication of this article was funded by the Qatar National Library.
Languageen
PublisherMDPI AG
SubjectBiomarkers
Breast cancer
Gene expression profiling
HER2-positive breast cancer
Microarray
miRNAs
TitleGene expression and miRNAs profiling: Function and regulation in human epidermal growth factor receptor 2 (HER2) - positive breast cancer
TypeArticle
Issue Number5
Volume Number11
dc.accessType Open Access


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