Antibodies against aberrant glycans as cancer biomarkers
| Author | Blsakova A. |
| Author | Kveton F. |
| Author | Kasak P. |
| Author | Tkac J. |
| Available date | 2020-04-01T06:50:39Z |
| Publication Date | 2019 |
| Publication Name | Expert Review of Molecular Diagnostics |
| Resource | Scopus |
| ISSN | 14737159 |
| Abstract | Introduction: The review provides a comprehensive overview about applicability of serological detection of autoantibodies against aberrant glycans as cancer biomarkers. Areas covered: Clinical usefulness of autoantibodies as cancer biomarkers is discussed for seven types of cancers with sensitivity and specificity of such biomarkers provided. Moreover, an option of using serological antibodies against a non-natural form of sialic acid�N-glycolylneuraminic acid (Neu5Gc), which is taken into our bodies together with red meat, as a potential cancer biomarker is discussed shortly as well. Expert opinion: In the final part of the review, we discuss what measures need to be applied for selective implementation of autoantibody assays into a clinical practice. Moreover, we discuss key challenges ahead for reliable and robust detection of autoantibodies against aberrant glycans as biomarkers for disease diagnostics and for stratification of cancer patients. - 2019, - 2019 Informa UK Limited, trading as Taylor & Francis Group. |
| Sponsor | The authors would like to acknowledge the financial support received from the Slovak Research and Development Agency APVV 17-0300. This work was supported by Ministry of Health of the Slovak Republic under the project registration number 2018/23-SAV-1. P. K. thanks that this work was also made possible by Qatar University grant QUCG-CAM-19/20-2. The finding achieved herein is solely the responsibility of the authors. |
| Language | en |
| Publisher | Taylor and Francis Ltd |
| Subject | Cancer diagnostics ELISA glycan microarrays predictive biomarkers prognosis |
| Type | Article Review |
| Pagination | 1057-1068 |
| Issue Number | 12 |
| Volume Number | 19 |
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