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AuthorBlsakova A.
AuthorKveton F.
AuthorKasak P.
AuthorTkac J.
Available date2020-04-01T06:50:39Z
Publication Date2019
Publication NameExpert Review of Molecular Diagnostics
ResourceScopus
ISSN14737159
URIhttp://dx.doi.org/10.1080/14737159.2020.1687295
URIhttp://hdl.handle.net/10576/13578
AbstractIntroduction: The review provides a comprehensive overview about applicability of serological detection of autoantibodies against aberrant glycans as cancer biomarkers. Areas covered: Clinical usefulness of autoantibodies as cancer biomarkers is discussed for seven types of cancers with sensitivity and specificity of such biomarkers provided. Moreover, an option of using serological antibodies against a non-natural form of sialic acid�N-glycolylneuraminic acid (Neu5Gc), which is taken into our bodies together with red meat, as a potential cancer biomarker is discussed shortly as well. Expert opinion: In the final part of the review, we discuss what measures need to be applied for selective implementation of autoantibody assays into a clinical practice. Moreover, we discuss key challenges ahead for reliable and robust detection of autoantibodies against aberrant glycans as biomarkers for disease diagnostics and for stratification of cancer patients. - 2019, - 2019 Informa UK Limited, trading as Taylor & Francis Group.
SponsorThe authors would like to acknowledge the financial support received from the Slovak Research and Development Agency APVV 17-0300. This work was supported by Ministry of Health of the Slovak Republic under the project registration number 2018/23-SAV-1. P. K. thanks that this work was also made possible by Qatar University grant QUCG-CAM-19/20-2. The finding achieved herein is solely the responsibility of the authors.
Languageen
PublisherTaylor and Francis Ltd
SubjectCancer diagnostics
ELISA
glycan microarrays
predictive biomarkers
prognosis
TitleAntibodies against aberrant glycans as cancer biomarkers
TypeArticle Review
Pagination1057-1068
Issue Number12
Volume Number19
dc.accessType Abstract Only


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