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AuthorJebaraj Walter, Charles Emmanuel
AuthorDurairajan, Sankari
AuthorPeriyandavan, Kalaiselvi
AuthorPriya Doss C, George
AuthorDavis G, Dicky John
AuthorVasanthi A, Hannah Rachel
AuthorJohnson, Thanka
AuthorZayed, Hatem
Available date2020-04-05T10:08:49Z
Publication Date2020-03-01
Publication NameExpert Review of Molecular Diagnostics
Identifierhttp://dx.doi.org/10.1080/14737159.2020.1743688
CitationCharles Emmanuel Jebaraj Walter, Sankari Durairajan, Kalaiselvi Periyandavan, George Priya Doss C, Dicky John Davis G, Hannah Rachel Vasanthi A, Thanka Johnson & Hatem Zayed (2020) Bladder neoplasms and NF-κB: an unfathomed association, Expert Review of Molecular Diagnostics, DOI: 10.1080/14737159.2020.1743688
ISSN1473-7159
URIhttp://hdl.handle.net/10576/13794
AbstractBladder cancer is the second most common genitourinary tract cancer and is often recurrent and/or chemoresistant after tumor resection. Cigarette smoking, exposure to aromatic amines, and chronic infection/inflammation are bladder cancer risk factors. NF-κB is a transcription factor that plays a critical role in normal physiology and bladder cancer. Bladder cancer patients have constitutively active NF-κB triggered by pro-inflammatory cytokines, chemokines, and hypoxia, augmenting carcinogenesis and progression.: NF-κB orchestrates protein interactions (PTEN, survivin, VEGF), regulation (CYLD, USP13) and gene expression (Trp 53) resulting in bladder cancer progression, recurrence and resistance to therapy. This review focuses on NF-κB in bladder inflammation, cancer and resistance to therapy.: NF-κB and bladder cancer necessitate further research to develop better diagnostic and treatment regimens that address progression, recurrence and resistance to therapy. NF-κB is a master regulator that can act with or on minimally one cancer hallmark gene or protein, leading to bladder cancer progression (Tp53, PTEN, VEGF, HMGB1, CYLD, USP13), recurrence (PCNA, BcL-2, JUN) and resistance to therapy (P-gp, twist, SETD6). Thus, an understanding of bladder cancer in relation to NF-κB will offer improved strategies and efficacious targeted therapies resulting in minimal progression, recurrence and resistance to therapy.
Languageen
PublisherTaylor & Francis
SubjectBladder cancer
NF-κB
chemoresistance
inflammation
signal transduction
TitleBladder neoplasms and NF-κB: an unfathomed association.
TypeArticle
ESSN1744-8352
dc.accessType Abstract Only


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