Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety
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التاريخ
2020-04المؤلف
Shaito, AbdullahThuan, Duong Thi Bich
Phu, Hoa Thi
Nguyen, Thi Hieu Dung
Hasan, Hiba
Halabi, Sarah
Abdelhady, Samar
Nasrallah, Gheyath K.
Eid, Ali H.
Pintus, Gianfranco
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البيانات الوصفية
عرض كامل للتسجيلةالملخص
Cardiovascular diseases (CVDs) are a significant health burden with an ever-increasing
prevalence. They remain the leading causes of morbidity and mortality worldwide. The use
of medicinal herbs continues to be an alternative treatment approach for several diseases
including CVDs. Currently, there is an unprecedented drive for the use of herbal
preparations in modern medicinal systems. This drive is powered by several aspects,
prime among which are their cost-effective therapeutic promise compared to standard
modern therapies and the general belief that they are safe. Nonetheless, the claimed
safety of herbal preparations yet remains to be properly tested. Consequently, public
awareness should be raised regarding medicinal herbs safety, toxicity, potentially lifethreatening
adverse effects, and possible herb–drug interactions. Over the years,
laboratory data have shown that medicinal herbs may have therapeutic value in CVDs
as they can interfere with several CVD risk factors. Accordingly, there have been many
attempts to move studies on medicinal herbs from the bench to the bedside, in order to
effectively employ herbs in CVD treatments. In this review, we introduce CVDs and their
risk factors. Then we overview the use of herbs for disease treatment in general and CVDs
in particular. Further, data on the ethnopharmacological therapeutic potentials and
medicinal properties against CVDs of four widely used plants, namely Ginseng, Ginkgo
biloba, Ganoderma lucidum, and Gynostemma pentaphyllum, are gathered and reviewed.
In particular, the employment of these four plants in the context of CVDs, such as
myocardial infarction, hypertension, peripheral vascular diseases, coronary heart disease,
cardiomyopathies, and dyslipidemias has been reviewed, analyzed, and critically
discussed. We also endeavor to document the recent studies aimed to dissect the
cellular and molecular cardio-protective mechanisms of the four plants, using recently
reported in vitro and in vivo studies. Finally, we reviewed and reported the results of the recent clinical trials that have been conducted using these four medicinal herbs with
special emphasis on their efficacy, safety, and toxicity.
المجموعات
- العلوم الحيوية الطبية [697 items ]