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المؤلفSkenderi, Faruk
المؤلفPalazzo, Juan
المؤلفSwensen, Jeffrey
المؤلفFeldman, Rebecca
المؤلفContreras, Elma
المؤلفFlorento, Elena
المؤلفGatalica, Zoran
المؤلفVranic, Semir
تاريخ الإتاحة2020-04-14T07:42:23Z
تاريخ النشر2020-04-11
اسم المنشورThe Breast Journal
المعرّفhttp://dx.doi.org/10.1111/tbj.13842
الاقتباسSkenderi, F, Palazzo, J, Swensen, J, et al. Novel targetable biomarkers in clear cell carcinoma of the breast uncovered by molecular profiling: A study of nine cases. Breast J. 2020; 00: 1– 3. https://doi.org/10.1111/tbj.13842
معرّف المصادر الموحدhttp://hdl.handle.net/10576/14122
الملخصWe profiled nine pure clear cell carcinomas of the breast using massively parallel DNA and RNA sequencing (NGS), in situ hybridization (ISH), and immunohistochemistry (IHC). All cases were primary mammary clear cell carcinomas that were diagnosed in female patients (mean age: 53.4 years; range: 31-69 years). Based on our findings, we conclude that the majority of clear cell carcinomas are ER/PR positive and consequently amenable to anti-ER treatment modalities. A subset of clear cell carcinomas also harbored alterations in PIK3CA/PTEN/AKT pathway, particularly PTEN, indicating a potential benefit of PI3K/Akt/mTOR inhibitors. The status of I-O biomarkers in clear cell carcinomas indicates a limited therapeutic benefit of immune checkpoint inhibitors (against PD-1/PD-L1).
اللغةen
الناشرWiley
الموضوعbreast cancer
clear cell carcinoma
immunotherapy
molecular profiling
targeted therapy
العنوانNovel targetable biomarkers in clear cell carcinoma of the breast uncovered by molecular profiling: A study of nine cases.
النوعArticle
dc.accessType Open Access


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