Show simple item record

AuthorHvidtfeldt, Ulla Arthur
AuthorSorensen, Mette
AuthorGeels, Camilla
AuthorMatthias, Ketzel
AuthorKhan, Jibran
AuthorTjonneland, Anne
AuthorOvervad, Kim
AuthorBrandt, Jorgen
AuthorRaaschou-Nielsen, Ole
Available date2020-05-15T00:15:02Z
Publication Date2019
Publication NameEnvironment International
ResourceScopus
ISSN1604120
URIhttp://dx.doi.org/10.1016/j.envint.2018.12.010
URIhttp://hdl.handle.net/10576/14897
AbstractAir pollutants such as NO2 and PM2.5 have consistently been linked to mortality, but only few previous studies have addressed associations with long-term exposure to black carbon (BC) and ozone (O3). We investigated the association between PM2.5, PM10, BC, NO2, and O3 and mortality in a Danish cohort of 49,564 individuals who were followed up from enrollment in 1993-1997 through 2015. Residential address history from 1979 onwards was combined with air pollution exposure obtained by the state-of-the-art, validated, THOR/AirGIS air pollution modelling system, and information on residential traffic noise exposure, lifestyle and socio-demography. We observed higher risks of all-cause as well as cardiovascular disease (CVD) mortality with higher long-term exposure to PM2.5, PM10, BC, and NO2. For PM2.5 and CVD mortality, a hazard ratio (HR) of 1.29 (95% CI: 1.13-1.47) per 5 g/m3 was observed, and correspondingly HRs of 1.16 (95% CI: 1.05-1.27) and 1.11 (95% CI: 1.04-1.17) were observed for BC (per 1 g/m3) and NO2 (per 10 g/m3), respectively. Adjustment for noise gave slightly lower estimates for the air pollutants and CVD mortality. Inverse relationships were observed for O3. None of the investigated air pollutants were related to risk of respiratory mortality. Stratified analyses suggested that the elevated risks of CVD and all-cause mortality in relation to long-term PM, NO2 and BC exposure were restricted to males. This study supports a role of PM, BC, and NO2 in all-cause and CVD mortality independent of road traffic noise exposure.
SponsorThe research was funded by NordForsk under the Nordic Programme on Health and Welfare (Project #75007: NordicWelfAir - Understanding the link between Air pollution and Distribution of related Health Impacts and Welfare in the Nordic countries). The funding source had no involvement in the study design, collection, analysis, interpretation, writing and decision to submit for publication.
Languageen
PublisherElsevier Ltd
SubjectBlack carbon
CVD
Epidemiology
Mortality
NO2
Ozone
Particulate matter
TitleLong-term residential exposure to PM2.5, PM10, black carbon, NO2, and ozone and mortality in a Danish cohort
TypeArticle
Pagination265-272
Volume Number123
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record