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المؤلفLevy-Gigi, Einat
المؤلفHaim-Nachum, Shilat
المؤلفHall, Julie M.
المؤلفCrousec , Jacob J.
المؤلفWinwood-Smith, Robyn
المؤلفLewis, Simon J.G.
المؤلفMoustafa, Ahmed A.
تاريخ الإتاحة2020-05-15T00:15:03Z
تاريخ النشر2019
اسم المنشورNeuroscience Letters
المصدرScopus
الرقم المعياري الدولي للكتاب3043940
معرّف المصادر الموحدhttp://dx.doi.org/10.1016/j.neulet.2018.11.006
معرّف المصادر الموحدhttp://hdl.handle.net/10576/14912
الملخصCognitive deficits in Parkinson’s disease (PD) have increasingly been recognized over the last decade and reversal learning in particular has received a great deal of attention. In a classical reversal-learning paradigm, participants learn to associate various stimuli with specific responses (i.e. A →Positive; B→ Negative), and subsequently learn to associate the same stimuli with opposite outcomes (i.e., A→Negative; B→ Positive). Prior studies have revealed that medicated PD patients have a selective impairment with learning from negative, but not positive, outcomes, even when both reward- and punishment-related stimuli were equally relevant. The aim of the present study was to further understand this impairment by applying a novel reversal-learning paradigm, which enables the differentiation between positive/negative and cue/context reversal impairments. Twenty-seven medicated PD patients and twenty-nine healthy individuals matched for age, gender and education completed the cue-context reversal learning paradigm. The results revealed no significant differences in context reversal learning between individuals with PD and healthy controls. However, in cue reversal learning, healthy controls were significantly better at performing positive-to-negative reversal trials compared to individuals with PD, while individuals with PD were significantly better in negative-to-positive reversal trials compared to healthy controls. As such, the present study distinguishes between different types of reversal learning and suggests that different neural circuits are responsible for context and cue learning. These results improve our understanding of the possible effects of dopaminergic medications and may have important clinical implications.
راعي المشروعThe research was supported by ISRAEL SCIENCE FOUNDATION (Grant# 1128/16 ) awarded to Einat Levy-Gigi.
اللغةen
الناشرElsevier Ireland Ltd
الموضوعContext
Cue
Dopamine
Learning
Parkinson's disease
Reversal
Valence
العنوانThe interactive effect of valence and context on reversal learning in individuals with Parkinson's disease
النوعArticle
الصفحات216-224
رقم المجلد692
dc.accessType Abstract Only


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