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المؤلفZolezzi, M.
المؤلفCheung, L.
تاريخ الإتاحة2020-06-23T20:45:41Z
تاريخ النشر2019
اسم المنشورNeuropsychiatric Disease and Treatment
المصدرScopus
الرقم المعياري الدولي للكتاب11766328
معرّف المصادر الموحدhttp://dx.doi.org/10.2147/NDT.S186474
معرّف المصادر الموحدhttp://hdl.handle.net/10576/15115
الملخصBackground: Certain psychotropics and a number of other medications used to treat medical conditions in psychiatric patients can increase the risk of prolonging the corrected QT (QTc) interval on the electrocardiogram, which puts patients at risk of life-threatening ventricular arrhythmias such as torsades de pointes. Pharmacists are often consulted about medications which are known to prolong the QTc interval. Although this information is often accessible, advising how to identify, assess, manage, and refer psychiatric patients at risk for drug-induced QTc prolongation is more challenging. Objectives: The objective of this project was first to review the literature, which describes guidelines and recommendations for the assessment and management of drug-induced QTc prolongation, and then to design an algorithm to be used by pharmacists working closely with mental health professionals or who provide care to psychiatric patients. Methods: A review of the literature was undertaken. Predefined keywords were used to perform the database search in MEDLINE, EMBASE, and International Pharmaceutical Abstracts to identify reviews, reports and guidelines on the assessment, prevention and monitoring of drug-induced QTc prolongation with an emphasis on psychotropic medications and management in the psychiatric population. Results: The electronic database search retrieved 637 relevant citations. These were initially screened by title and all duplicates were removed. The abstracts were then reviewed for relevancy based on the inclusion/exclusion criteria. Additional citations were retrieved from the bibliography of the articles identified in the initial search. A total of 79 articles describing QTc prolongation in the psychiatric population were thoroughly examined, but only 31 articles were selected to guide the development of the algorithm. Conclusion: The literature-based algorithm developed provides a stepped-based approach for the assessment, monitoring, and management of drug-induced QTc prolongation in the psychiatric population. The algorithm may assist mental health clinicians in the decision-making process when psychiatric patients are prescribed medications known to increase the QTc interval. - 2019 Zolezzi and Cheung.
اللغةen
الناشرDove Medical Press Ltd.
الموضوعAlgorithm
Drug-induced arrhythmias
Guidelines
Mental
Patients
Protocol
QT interval
Torsades de pointes
العنوانA literature-based algorithm for the assessment, management, and monitoring of drug-induced QTc prolongation in the psychiatric population
النوعArticle Review
الصفحات105-114
رقم المجلد15
dc.accessType Open Access


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