Prenatal alcohol exposure is associated with early motor, but not language development in a South African cohort
التاريخ
2019المؤلف
Hendricks, GaironeesaMalcolm-Smith, Susan
Stein, Dan J.
Zar, Heather J.
Wedderburn, Catherine J.
Nhapi, Raymond T.
Chivese, Tawanda
Adnams, Colleen M.
Donald, Kirsten A.
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البيانات الوصفية
عرض كامل للتسجيلةالملخص
Objective:To investigate the association of prenatal alcohol exposure (PAE) and early neurodevelopment in the first 2 years of life, adjusting for maternal sociodemographic and psychosocial factors, in the Drakenstein Child Health Study (DCHS), a South African birth cohort study.Methods:The DCHS comprises a population-based birth cohort of 1143 children, of which, a subsample completed the Bayley Scales of Infant Development-III (BSID-III) at 6 (n = 260) and 24 months of age (n = 734). A subset of alcohol exposed, and unexposed children was included in this analysis at age 6 months (n = 52 exposed; n = 104 unexposed) and 24 months (n = 92 exposed; n=184 unexposed). Multiple hierarchical regression was used to explore the associations of PAE with motor and language development.Results:PAE was significantly associated with decreased gross motor (OR = 0.16, 95%CI 0.06-0.44, p = 0.001) or fine motor (OR = 0.16, 95%CI 0.06-0.46, p = 0.001) functioning after adjusting for maternal sociodemographic and psychosocial factors at 6 months of age only. No significant effects were found in either receptive or expressive communication and cognitive outcomes at either time point.Conclusion:PAE has potentially important consequences for motor development in the first 2 years of life, a period during which the most rapid growth and maturation occurs. These findings highlight the importance of identifying high-risk families in order to provide preventive interventions, particularly in antenatal clinics and early intervention services. - 2020 Scandinavian College of Neuropsychopharmacology.
المجموعات
- أبحاث الطب [1382 items ]