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AuthorRiaz, Sadaf
AuthorZeidan, Asad
AuthorMraiche, Fatima
Available date2020-08-27T12:05:52Z
Publication Date2017
Publication NameJournal of Cellular Physiology
ResourceScopus
ISSN219541
URIhttp://dx.doi.org/10.1002/jcp.25884
URIhttp://hdl.handle.net/10576/15845
AbstractCardiac hypertrophy (CH), characterized by the enlargement of cardiomyocytes, fibrosis and apoptosis, is one of the leading causes of death worldwide. Despite the advances in cardiovascular research, there remains a need to further investigate the signaling pathways that mediate CH in order to identify novel therapeutic targets. One of the hallmarks of CH is the remodeling of the extracellular matrix (ECM). Multiple studies have shown an important role of cysteine proteases and matrix metalloproteinases (MMPs) in the remodeled heart. This review focuses on the role of cysteine cathepins and MMPs in cardiac remodeling. - 2017 Wiley Periodicals, Inc.
Languageen
PublisherWiley-Liss Inc.
Subjectcardiac remodeling
cathepsins
extracellular matrix
heart failure
matrix metalloproteinases
TitleMyocardial proteases and cardiac remodeling
TypeArticle Review
Pagination3244-3250
Issue Number12
Volume Number232
dc.accessType Abstract Only


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