Co-incidence of Human Papillomaviruses and Epstein-Barr Virus Is Associated With High to Intermediate Tumor Grade in Human Head and Neck Cancer in Syria.
المؤلف | Gupta, Ishita |
المؤلف | Ghabreau, Lina |
المؤلف | Al-Thawadi, Hamda |
المؤلف | Yasmeen, Amber |
المؤلف | Vranic, Semir |
المؤلف | Al Moustafa, Ala-Eddin |
المؤلف | Malki, Mohammed I |
تاريخ الإتاحة | 2020-09-27T04:56:38Z |
تاريخ النشر | 2020-08-20 |
اسم المنشور | Frontiers in Oncology |
المعرّف | http://dx.doi.org/10.3389/fonc.2020.01016 |
الاقتباس | Gupta I, Ghabreau L, Al-Thawadi H, Yasmeen A, Vranic S, Al Moustafa A-E and Malki MI (2020) Co-incidence of Human Papillomaviruses and Epstein–Barr Virus Is Associated With High to Intermediate Tumor Grade in Human Head and Neck Cancer in Syria. Front. Oncol. 10:1016. doi: 10.3389/fonc.2020.01016 |
الملخص | High-risk human papillomaviruses (high-risk HPVs) have been recently reported to be co-present with Epstein-Barr virus (EBV) in different types of human cancers including head and neck (HN), where they can cooperate in the initiation and/or progression of this cancer. Accordingly, we herein explored the prevalence of high-risk HPVs and EBV in 80 HN cancer tissues from the Syrian population using polymerase chain reaction, immunohistochemistry, and tissue microarray methodologies. We report that high-risk HPVs and EBV are present in 35/80 (43.7%) and 41/80 (51.2%) of our samples, respectively, and the most frequent HPV types are 33, 16, 18, 45, 52, 58, 35, 51, and 31, in this order. More significantly, our data reveal that 25/80 (31.2%) of cancer cases are positive for high-risk HPVs as well as EBV, and their co-presence is associated with high/intermediate-grade squamous cell carcinomas. These data confirm the co-presence of high-risk HPVs and EBV in HN cancers in the Syrian population of the Middle East and demonstrate that their co-incidence is linked to a more aggressive cancer phenotype. Thus, future studies are required to confirm these data and elucidate the exact role of high-risk and EBV cooperation in human HN carcinogenesis. |
راعي المشروع | This work was supported by Qatar University grants # QUHI-CMED-19/20-1 and GCC-2017-002 QU/KU. |
اللغة | en |
الناشر | Frontiers Media |
الموضوع | Epstein–Barr virus Syrian population head and neck cancers human papillomaviruses tumor grade |
النوع | Article |
الصفحات | 1016 |
رقم المجلد | 10 |
ESSN | 2234-943X |
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